Overexpression of periostin in stroma positively associated with aggressive prostate cancer

PloS One
Yuan TianHui Zhang

Abstract

Periostin is an important extracellular matrix protein involved in cell development and adhesion. Previously, we identified periostin to be up-regulated in aggressive prostate cancer (CaP) using quantitative glycoproteomics and mass spectrometry. The expression of periostin was further evaluated in primary radical prostatectomy (RP) prostate tumors and adjacent non-tumorous prostate tissues using immunohistochemistry (IHC). Our IHC results revealed a low background periostin levels in the adjacent non-tumorous prostate tissues, but overexpressed periostin levels in the peritumoral stroma of primary CaP tumors. In this study, periostin expression in CaP was further examined on multiple tissue microarrays (TMAs), which were conducted in four laboratories. To achieve consistent staining, all TMAs were stained with same protocol and scored by same image computation tool to determine the total periostin staining intensities. The TMAs were further scored by pathologists to characterize the stromal staining and epithelial staining. The periostin staining was observed mainly in peritumoral stromal cells and in some cases in tumor epithelial cells though the stronger staining was found in peritumoral stromal cells. Both periostin stroma...Continue Reading

References

Mar 14, 2007·Journal of Clinical Pathology·B S M S SiriwardenaT Takata
Oct 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David B SeligsonBenjamin Bonavida
Apr 30, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshinao KikuchiMasashi Fukayama
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maryla KrajewskaJohn C Reed
Mar 25, 2009·Cellular and Molecular Life Sciences : CMLS·Kai RuanGaoliang Ouyang
Jun 11, 2010·BMC Cancer·Verena TischlerGlen Kristiansen
Aug 7, 2010·Gynecologic Oncology·Min ZhuDennis J Slamon
Dec 15, 2010·BMC Cancer·Erin L MareshLee Goodglick
Nov 15, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Laura MorraAlex Soltermann
Jan 26, 2013·Cancer Biotherapy & Radiopharmaceuticals·Guoqiang WuXuefeng Zhang

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Citations

May 30, 2015·International Journal of Molecular Sciences·Zewu LiChuanxin Wang
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhangXin Su
Nov 1, 2017·Journal of Cell Communication and Signaling·Akira Kudo, Isao Kii
Sep 10, 2017·Cellular and Molecular Life Sciences : CMLS·Isao Kii, Harumi Ito
Feb 6, 2017·British Journal of Cancer·Annie RochetteAxel A Thomson
Jun 28, 2018·Frontiers in Oncology·Laura González-González, Javier Alonso
Sep 26, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Guangjing ZhuRobert W Veltri
Nov 21, 2020·Virchows Archiv : an International Journal of Pathology·Takahiro SueyamaHideki Ueno
Jul 20, 2016·Journal of Proteome Research·Chang-Hsu ChiangAnn-Joy Cheng

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