Overexpression of Pim-1 during progression of prostatic adenocarcinoma

Journal of Clinical Pathology
T L CibullL Cheng

Abstract

Pim-1 is a serine/threonine kinase that has been shown to play an integral role in the development of a number of human cancers, such as haematolymphoid malignancies. Recently, evidence has shown Pim-1 to be important in prostatic carcinogenesis. In order to further our understanding of its role in prostate cancer, we investigated Pim-1 expression in normal, premalignant, and malignant prostate tissue. Using immunohistochemistry, Pim-1 expression was analysed in prostate tissue from 120 radical prostatectomy specimens. In each case, Pim-1 staining was evaluated in benign prostatic epithelium, high grade prostatic intraepithelial neoplasia (PIN), and prostatic adenocarcinoma. The number of positively staining cells was estimated, and the intensity of staining was scored on a scale of 0 to 3+. Pim-1 immunoreactivity was identified in 120 cases (100%) of adenocarcinoma, 120 cases (100%) of high grade PIN, and 62 cases (52%) of benign glands. The number of cells staining in benign epithelium (mean 34%) was much lower than that in high grade PIN (mean 80%; p<0.0001) or adenocarcinoma (mean, 84%; p<0.0001). There was no significant difference between high grade PIN and adenocarcinoma in the percentage of cells staining positively for...Continue Reading

References

Jun 15, 1996·Archives of Biochemistry and Biophysics·H LiangL Nagarajan
Feb 14, 1998·Journal of the National Cancer Institute·L ChengZ Zhuang
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Oct 3, 2003·Cancer Cell·Katharine Ellwood-YenCharles L Sawyers
Nov 25, 2003·The American Journal of Pathology·Guangyuan ZengLiang Cheng

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Citations

Oct 14, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Benedict YanUNKNOWN Singapore Gastric Cancer Consortium
Dec 15, 2010·Nature Reviews. Cancer·Martijn C NawijnAnton Berns
Nov 11, 2010·The Journal of Biological Chemistry·Daisuke MorishitaNaoya Fujita
Oct 25, 2008·Advances in Anatomic Pathology·Bora GurelAngelo M De Marzo
Jul 22, 2010·Molecular Cancer Research : MCR·Marina ZemskovaAndrew S Kraft
Jun 18, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jolyane MelocheSébastien Bonnet
Nov 15, 2011·American Journal of Respiratory Cell and Molecular Biology·Yoo Seob ShinErwin W Gelfand
Dec 6, 2011·PloS One·Vera MagistroniCarlo Gambacorti-Passerini
Oct 6, 2010·Future Oncology·Nancy S MagnusonRaymond Reeves
Jan 15, 2015·Future Medicinal Chemistry·Bich Thuy LeShudong Wang
Mar 6, 2012·Expert Opinion on Investigational Drugs·Anna Lena MerkelMatthias Ocker
Dec 11, 2014·Journal of Hematology & Oncology·Patrizia MondelloMichael Mian
Mar 10, 2015·Pharmacology & Therapeutics·Noel A Warfel, Andrew S Kraft
Nov 15, 2011·Cellular Immunology·Leila J JacksonLaura L Carter
Jun 24, 2014·Neoplasia : an International Journal for Oncology Research·Jason M FoulksSteven B Kanner
May 24, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Methvin IsaacJan Jongstra
Mar 5, 2016·Experimental Cell Research·Niina M SantioPäivi J Koskinen
Aug 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nilesh ShahManuel Salto-Tellez
Oct 9, 2007·Trends in Biochemical Sciences·Tom CrabbeStephen G Ward
Nov 3, 2009·International Journal of Experimental Pathology·Min En NgaKakoli Das
Aug 8, 2015·Inorganic Chemistry·Rajathees RajaratnamEric Meggers
Nov 13, 2012·Molecular and Cellular Endocrinology·Marjo MalinenJorma J Palvimo
Aug 2, 2011·Leukemia Research·Amir T FathiMark Levis
Feb 18, 2017·Genes·Richard J RebelloLuc Furic
Apr 27, 2017·Journal of Medicinal Chemistry·Xiaojing WangJae H Chang
Jun 29, 2017·Immunological Reviews·Erwin W GelfandMichaela Schedel
May 11, 2013·Pulmonary Circulation·Sébastien RenardSteeve Provencher
Aug 29, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Molly LinJae H Chang
Jul 24, 2015·Journal of Virology·Chorong ParkSoon B Hwang
Mar 22, 2019·Physical Chemistry Chemical Physics : PCCP·Xiaohui Wang, Zhaoxi Sun

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