Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma

International Journal of Oncology
Qi CaoXiaoPing Zhang

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation. In addition, it has been observed to be elevated in numerous types of cancer, including ccRCC; however, its essential function remains unclear in ccRCC. The present study examined the expression of PLIN2 in ccRCC, and aimed to determine the association between PLIN2 expression and patient survival. The present study mined the transcriptional, clinicopathological and survival data of PLIN2 in patients with ccRCC through The Cancer Genome Atlas. The expression levels of PLIN2 were also detected in human ccRCC tissues and cell lines by western blotting and immunohistochemistry, and its biological role was identified by functional analysis. The results demonstrated that PLIN2 was predominantly elevated in RCC tissues and cells. In addition, the expression levels of PLIN2 were significantly associated with various clinicopathological factors, and high PLIN2 expression was associated with a good prognosis. The results of a multivariate analysis demonst...Continue Reading

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Citations

Nov 14, 2019·International Journal of Molecular Sciences·Prasanta DeyHyung Sik Kim
Feb 20, 2020·International Journal of Cancer. Journal International Du Cancer·Dongfang TangQingyi Wei
Feb 8, 2020·Cell Death & Disease·André L S CruzPatricia T Bozza
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May 7, 2021·Journal of Clinical Pathology·Feng-Zeng LiSheng Fang
Jun 3, 2021·International Journal of Molecular Sciences·Paola Berenice Mass SanchezAnastasia Asimakopoulos

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Methods Mentioned

BETA
transfection

Software Mentioned

GSEA
SPSS
Basic Local Alignment Search Tool
GraphPad Prism
Xena Explorer

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