Overexpression of s6 kinase 1 in brain tumours is associated with induction of hypoxia-responsive genes and predicts patients' survival.

Journal of Oncology
Heba M S Ismail

Abstract

mTOR/S6K pathway is a crucial regulator of cell growth and metabolism. Deregulated signalling via S6K has been linked to various human pathologies, including metabolic disorders and cancer. Many of the molecules signalling upstream of S6K have been shown to be either mutated or overexpressed in tumours, leading to S6K activation. The role of S6K1 in brain tumours is not fully investigated. In this study, we investigated the gene expression profile of S6 kinases in brain and CNS tumours using the publically available Cancer Microarray Database. We found that S6K1 but not S6K2 gene is overexpressed in brain tumours and this upregulation is associated with patients' poor survival. Furthermore, we interrogated Oncomine database for the expression profile of hypoxia-induced genes using a literature-defined concept. This gene list included HIF1A, VEGFA, SOX4, SOX9, MMP2, and NEDD9. We show that those genes are upregulated in all brain tumour studies investigated. Additionally, we analysed the coexpression profile of S6K1 and hypoxia responsive genes. The analysis was done across 4 different brain studies and showed that S6K1 is co-overexpressed with several hypoxia responsive genes. This study highlights the possible role of S6K1 in ...Continue Reading

References

Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J WongB Vogelstein
Aug 3, 2000·Journal of the National Cancer Institute·M BärlundA Kallioniemi
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·O MonniA Kallioniemi
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Sep 18, 2002·Biochemical Pharmacology·Jie Chen, Yimin Fang
Aug 2, 2003·Oncogene·Ruty ShaiStanley F Nelson
Oct 16, 2003·Biochemical and Biophysical Research Communications·Ning GaoXianglin Shi
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnab ChakravartiJay S Loeffler
Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janice P Dutcher
Feb 3, 2005·Acta Neuropathologica·Hiroko Ohgaki, Paul Kleihues
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroko Ohgaki
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangMark A Israel
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evanthia GalanisUNKNOWN North Central Cancer Treatment Group
Dec 17, 2005·Cancer Research·Pim J FrenchPeter A Sillevis Smitt
Feb 18, 2006·Molecular Cell·Liping LiuM Celeste Simon
May 16, 2007·The Journal of Biological Chemistry·Stephen C Land, Andrew R Tee
Jul 11, 2007·Molecular Cancer Therapeutics·Antonio M P OmuroEric Raymond
Aug 19, 2007·Cancer Cell·Joan BruggeGordon B Mills
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liu Hua WeiWolfgang A Weber
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anastasia MuratMonika E Hegi
Aug 15, 2008·Cancer Research·Jean L NakamuraRussell O Pieper
Dec 17, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Zul KaderaliJames T Rutka
Jun 30, 2009·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Aug 4, 2009·Neuroepidemiology·Bridget J McCarthyBeatrice Malmer
Apr 13, 2011·Chemical Society Reviews·Ida Karin Nordgren, Ali Tavassoli

❮ Previous
Next ❯

Citations

Jun 12, 2012·Medical Oncology·Pin Dong LiHui Yun Wang
Dec 17, 2014·Molecular Biology International·Mehvish ShowkatKhurshid I Andrabi
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Varadharajan ThiyagarajanChing-Feng Weng
Aug 8, 2014·Journal of Clinical Pathology·Farnaz Bahrami-BDavid L Morris
Mar 15, 2018·Nutrition and Cancer·Sara Bianchi, Luca Giovannini
Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dinh-Chuong PhamChing-Feng Weng
Aug 14, 2015·Physiological Reviews·Joël Bockaert, Philippe Marin

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
surgical resection

Software Mentioned

GraphPad prism
Oncomine
GraphPad

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.