Overexpression of serum lncRNA-ABHD11-AS1 as poor prognosis of patients with papillary thyroid carcinoma.

Experimental and Molecular Pathology
Sen HouCheng-He Lin

Abstract

This paper was aimed at exploring the correlation of long non-coding RNA (lncRNA)-ABHD11 Antisense RNA1 (ABHD11-AS1) with the poor prognosis of patients with papillary thyroid carcinoma (PTC) and at investigating its effects on the survival of PTC cells. Serum was respectively collected from 64 PTC patients who were admitted to our hospital (PTC group) and from 50 healthy controls who underwent physical examinations (HC group) both from April 2011 to April 2015. The expression levels of ABHD11-AS1 in the serum were detected, and the values of it for diagnosis and prognosis (5-year follow-ups) were analyzed. The knockdown and overexpression models of ABHD11-AS1 in were constructed to explore the effects of the models on their proliferation, cycles and apoptosis. According to the data, the expression levels of serum ABHD11-AS1 in the PTC patients were remarkably higher than those in the healthy controls, and the area under the curve (AUC) for distinguishing the patients from the controls was 0.920. In the analysis of prognosis, the levels in patients with a poor prognosis were remarkably higher than those in patients with a good prognosis. According to the curves of overall survival rates (OSRs), the high levels of ABHD11-AS1 wer...Continue Reading

References

Aug 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yunben YangJunming Guo
Jan 8, 2017·World Journal of Surgical Oncology·Lei DaiXianjiang Wu
May 26, 2018·Journal of Cellular and Molecular Medicine·Yao LiuYang Zhao
Jul 26, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Meng CuiSuxia Luo
May 26, 2020·RNA Biology·Sergey D EgranovLiuqing Yang
Jul 18, 2020·Biomarkers in Medicine·Qian XiaoZhaowei Meng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis