Overexpression of SOX-2 is Associated with Better Overall Survival in Squamous Cell Lung Cancer Patients Treated with Adjuvant Radiotherapy

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Hong In YoonYong Bae Kim

Abstract

The purpose of this study is to investigate the prognostic significance of SOX-2 gene amplification and expression in patients with American Joint Committee on Cancer stage III lung squamous cell carcinoma (SCC) who underwent surgery followed by adjuvant radiotherapy. Pathological specimens were obtained from 33 patients with stage III lung SCC treated with surgery followed by adjuvant radiotherapy between 1996 and 2008. SOX-2 gene amplification and protein expression were analyzed using fluorescent in situ hybridization and immunohistochemistry, respectively. Patients were divided into two groups according to their SOX-2 gene amplification and protein expression status. Kaplan-Meier estimates and a Cox proportional hazards model were used to identify the prognostic factors affecting patient survival. The median follow-up period for surviving patients was 58 months (range, 5-102). SOX-2 gene amplification was observed in 22 patients and protein overexpression in 26 patients. SOX-2 overexpression showed significant association with SOX-2 gene amplification (P=0.002). In multivariate analysis, SOX-2 overexpression was a significant prognostic factor for overall survival (OS) (Hazard ratios (HR) 0.1, 95% confidence interval (CI) 0...Continue Reading

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BETA
immunoprecipitation

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