Overexpression of SSH1 in gastric adenocarcinoma and its correlation with clinicopathological features

Journal of Gastrointestinal Oncology
Seyedeh Saideh DaryabariBehrooz Shokouhi

Abstract

Gastric adenocarcinoma is known to be the fourth most common cancer type and the second cause of cancer-related deaths. Movement and invasion of cancer cells is one of the major characteristics of the cancer phenotype that various types of network regulate this. Expression levels of slingshot diphosphatase 1 (SSH1) gene has been modulated in this pathway. SSH1 acts as a dephosphorylation and activator of cofilin that this regulating and activating by SSH1 can play a major role in the mobility and migration of the cell. The aim of this study was to compare the expression level of SSH1 genes between tumor and corresponding adjacent non tumor gastric tissues and healthy tissue of gastric adenocarcinoma. In this study, mRNA of 40 gastric adenocarcinoma and corresponding adjacent non tumor gastric tissues and 15 healthy biopsy samples was extracted, then after cDNA synthesis, real-time polymerase chain reaction was performed to measure gene expression. According to REST analysis, the relative expression of SSH1 was significantly increased in gastric cancer tissues compared to the corresponding adjacent non tumor gastric tissue samples and normal tissue. Nevertheless, the result revealed no substantial correlation between the express...Continue Reading

Citations

Jun 28, 2019·American Journal of Clinical Pathology·Yan WangYing Liu
Jul 18, 2019·Bioscience, Biotechnology, and Biochemistry·Quan-Hui LiYu-Xin Chen
Nov 27, 2019·Journal of Gastrointestinal Cancer·Haniye MohammadrezakhaniReza Safaralizadeh
Feb 6, 2020·Journal of Gastroenterology and Hepatology·Xiangping SongHaiping Pei
Jul 18, 2020·Molecular Biology Reports·Shiva RezaeiReza Safaralizadeh
May 9, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ping-Ping GaoYi Zhang

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