Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours.

British Journal of Cancer
J GreenA Storey

Abstract

The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorly understood. We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell that mimic disease progression with the aim of identifying genes that may potentially contribute towards squamous cell carcinoma (SCC) progression in vivo, and in particular to identify markers that may serve as potential therapeutic targets for SCC treatment. Gene expression differences were corroborated by polymerase chain reaction and Western blotting. We identified Axl, a receptor tyrosine kinase with transforming potential that has also been shown to have a role in cell survival, adhesion and chemotaxis, was upregulated in vitro in SCC-derived cells compared to premalignant cells. Extending the investigation to tumour biopsies showed that the Axl protein was overexpressed in vivo in a series of SCCs.

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Citations

Oct 10, 2007·Molecular and Cellular Biology·Timothée RevilBenoit Chabot
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Mar 15, 2008·Cancer Research·Yi-Xiang ZhangAxel Ullrich

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Methods Mentioned

BETA
Chips
Fluorescence
chip
biopsies

Software Mentioned

JMP
SAS
Arcus Quickstat
KS400

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