PMID: 7541721Jul 14, 1995Paper

Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation

Cell
C L HallE A Turley

Abstract

Overexpression of the RHAMM gene by transfection into fibroblasts is transforming and causes spontaneous metastases in the lung. H-ras-transformed fibrosarcomas transfected with a dominant suppressor mutant of RHAMM exhibit a so-called revertant phenotype and are completely nontumorigenic and nonmetastatic. Conversely, fibroblasts stably expressing low levels of RHAMM as a result of antisense transfection are resistant to ras transformation. Collectively, these results indicate that RHAMM acts downstream of ras. The loss of functional RHAMM ablates signaling within focal adhesions, in particular changes in focal adhesion kinase phosphorylation, and as a result these focal adhesions are unable to turn over in response to hyaluronan. These results provide evidence of the oncogenic potential of a novel extracellular matrix receptor and establish a functional link between transformation by ras and signaling within focal adhesions that are required for transformation by this oncogene.

References

Jun 1, 1992·The Journal of Cell Biology·C HardwickE A Turley
Mar 1, 1992·Cancer Metastasis Reviews·E A Turley
Nov 11, 1992·International Journal of Cancer. Journal International Du Cancer·L BorsiL Zardi
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Nov 1, 1991·The Journal of Cell Biology·J E Murphy-UllrichM Höök
Oct 1, 1991·The Journal of Experimental Medicine·M S SyI Stamenkovic
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GunningL Kedes
Sep 1, 1989·The Journal of Cell Biology·J E Murphy-Ullrich, M Höök
Mar 1, 1988·Collagen and Related Research·A Woods, J R Couchman
Oct 30, 1986·Biochemical and Biophysical Research Communications·D HiroY Mori
Jan 1, 1993·Connective Tissue Research·K HoareE A Turley
Jul 1, 1994·The Journal of Experimental Medicine·A BartolazziI Stamenkovic
Nov 1, 1993·The Journal of Cell Biology·S K SamuelA H Greenberg
Oct 1, 1994·Current Opinion in Cell Biology·M D Schaller, J T Parsons
Mar 1, 1994·Cancer Metastasis Reviews·S H Lo, L B Chen
Jan 1, 1993·Annual Review of Cell Biology·W G Stetler-StevensonL A Liotta
Jun 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C Q Lin, M J Bissell
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
Mar 15, 1993·The Biochemical Journal·L KlewesP Prehm

❮ Previous
Next ❯

Citations

Dec 5, 1998·Microscopy Research and Technique·R H GoldbrunnerJ C Tonn
Jun 15, 1996·Journal of Cellular Biochemistry·J EntwistleE A Turley
Dec 1, 1995·Journal of Neuro-oncology·C L Hall, E A Turley
Apr 27, 2005·Journal of Computer-aided Molecular Design·Michael R Ziebell, Glenn D Prestwich
Mar 31, 2005·Biochemical and Biophysical Research Communications·Chu-Wen YangChen-Kung Chou
Jun 23, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·C L HallE A Turley
May 6, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·B B YangB L Yang
Jun 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alessandro LugliJeremy R Jass
Jan 26, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·M Veiseh, E A Turley
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W Y Chen, G Abatangelo
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Varki
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M F Meyer, G Kreil
Jun 19, 2010·The Journal of Biological Chemistry·Cornelia TolgEva A Turley
Nov 3, 2012·The Journal of Biological Chemistry·Cuixia YangFeng Gao
Apr 1, 1996·The Journal of Experimental Medicine·S MohapatraA H Greenberg
Nov 7, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·T LiebM Salathe
Jun 17, 2003·Molecular Biology of the Cell·Christopher A MaxwellLinda M Pilarski
Apr 25, 2002·Glycobiology·Bryan P Toole
May 1, 2001·Alcoholism, Clinical and Experimental Research·S FlemingE S Metcalf
Oct 16, 1999·The Journal of Eukaryotic Microbiology·M Jerka-DziadoszW Krawczyńska
May 18, 2007·Annual Review of Cell and Developmental Biology·Dianhua JiangPaul W Noble
Jan 21, 2011·Physiological Reviews·Dianhua JiangPaul W Noble
Mar 9, 2012·Biochemistry Research International·Mairim Alexandra SolisLynn L H Huang
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Gerard M Turino, Jerome O Cantor
Jul 23, 2005·American Journal of Respiratory Cell and Molecular Biology·Aisha ZamanRashmin C Savani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.