Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures

Epilepsy & Behavior : E&B
D López-LópezD E López

Abstract

Genetic animal models of epilepsy are an important tool for further understanding the basic cellular mechanisms underlying epileptogenesis and for developing novel antiepileptic drugs. We conducted a comparative study of gene expression in the inferior colliculus, a nucleus that triggers audiogenic seizures, using two animal models, the Wistar audiogenic rat (WAR) and the genetic audiogenic seizure hamster (GASH:Sal). For this purpose, both models were exposed to high intensity auditory stimulation, and 60min later, the inferior colliculi were collected. As controls, intact Wistar rats and Syrian hamsters were subjected to stimulation and tissue preparation protocols identical to those performed on the experimental animals. Ribonucleic acid was isolated, and microarray analysis comparing the stimulated Wistar and WAR rats showed that the genomic profile of these animals displayed significant (fold change, |FC|≥2.0 and p<0.05) upregulation of 38 genes and downregulation of 47 genes. Comparison of gene expression profiles between stimulated control hamsters and stimulated GASH:Sal revealed the upregulation of 10 genes and the downregulation of 5 genes. Among the common genes that were altered in both models, we identified the zin...Continue Reading

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Citations

May 17, 2017·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoJosé A Cortes de Oliveira
Jun 22, 2018·Systems Biology in Reproductive Medicine·Eduardo H UmeokaPaula A Navarro
Mar 14, 2020·PloS One·Elena Díaz-CasadoDolores E López
Nov 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hye-Ryun KimHaengseok Song
Jun 13, 2020·Frontiers in Neuroscience·Sandra M Díaz-RodríguezDolores E Lopéz
Nov 7, 2019·Epilepsy & Behavior : E&B·José Ramón BosqueDolores E López
Feb 9, 2021·Frontiers in Behavioral Neuroscience·Giselda Cabral-PereiraRicardo Gómez-Nieto
Jun 29, 2021·Frontiers in Neurology·Samara DamascenoAna Lúcia Brunialti Godard
Sep 12, 2020·CNS & Neurological Disorders Drug Targets·Shareen SinghAshish Kumar Rehni

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