Overexpression of the long noncoding RNA TUG1 protects against cold-induced injury of mouse livers by inhibiting apoptosis and inflammation

The FEBS Journal
Song SuXianming Xia

Abstract

Hepatic injury provoked by cold storage is a major problem affecting liver transplantation, as exposure to cold induces apoptosis in hepatic tissues. Long noncoding RNAs (lncRNAs) are increasingly understood to regulate apoptosis, but the contribution of lncRNAs to cold-induced liver injury remains unknown. Using RNA-seq, we determined the differential lncRNA expression profile in mouse livers after cold storage and found that expression of the lncRNA TUG1 was significantly down-regulated. Overexpression of TUG1 attenuated cold-induced apoptosis in mouse hepatocytes and liver sinusoidal endothelial cells LSECs, in part by blocking mitochondrial apoptosis and endoplasmic reticulum (ER) stress pathways. Moreover, TUG1 attenuated apoptosis, inflammation, and oxidative stress in vivo in livers subjected to cold storage. Overexpression of TUG1 also improved hepatocyte function and prolonged hepatic graft survival rates in mice. These results suggest that the lncRNA TUG1 exerts a protective effect against cold-induced liver damage by inhibiting apoptosis in mice, and suggests a potential role for TUG1 as a target for the prevention of cold-induced liver damage in liver transplantation. RNA-seq data are available from GEO using access...Continue Reading

References

Apr 1, 1988·Transplantation·F O Belzer, J H Southard
Sep 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T PiratvisuthR Williams
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W GaoP A Clavien
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R CursioA P Auberger
Mar 22, 2002·Transplantation·Charles J ImberPeter J Friend
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Abdulla K SalahudeenJohn K Jenkins
Jul 24, 2004·American Journal of Physiology. Renal Physiology·Abdulla K Salahudeen
Oct 9, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·E S Baskin-BeyG J Gores
Mar 30, 2005·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
Sep 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shin HwangDong-Goo Kim
Feb 1, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Richard S MangusJonathan A Fridell
May 3, 2006·Human Molecular Genetics·John S Mattick, Igor V Makunin
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donna Beer StolzNoriko Murase
Apr 2, 2010·Current Opinion in Cell Biology·Ling-Ling Chen, Gordon G Carmichael
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A S KleinA O Ojo
Apr 27, 2011·Current Medicinal Chemistry·C Peralta, C Brenner
Mar 10, 2012·Cell Death & Disease·I B MosbahJ Roselló-Catafau
Sep 11, 2012·Journal of Surgical Oncology·Yonghua HanZhiming Cai
Oct 30, 2012·Circulation Research·Nicole SchonrockJohn S Mattick
Apr 17, 2013·The Journal of Surgical Research·Bostjan HumarYinghua Tian
May 3, 2013·The Journal of Clinical Investigation·Laurie D DeLeve
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Qiang ZhangJie Yao
Jul 3, 2013·Journal of Hepatology·Carmen PeraltaJordi Gracia-Sancho
Dec 4, 2013·Nature Reviews. Genetics·Alessandro Fatica, Irene Bozzoni
Mar 15, 2014·International Journal of Cell Biology·Marianna Nicoletta Rossi, Fabrizio Antonangeli
May 14, 2014·Free Radical Biology & Medicine·Gaetano ServiddioAnna Maria Giudetti
Aug 13, 2014·Trends in Immunology·James A Heward, Mark A Lindsay
Feb 14, 2015·Circulation Research·Shizuka Uchida, Stefanie Dimmeler

❮ Previous
Next ❯

Citations

Jun 24, 2017·American Journal of Physiology. Cell Physiology·Mari McMahonEric Chevet
Dec 19, 2017·The FEBS Journal·Emily J Chenette, Seamus J Martin
Nov 21, 2017·F1000Research·Alexander McQuiston, J Alan Diehl
Aug 26, 2020·Bioscience, Biotechnology, and Biochemistry·Lili HuJianjun Liao
Oct 1, 2020·Journal of Cellular and Molecular Medicine·Rongsheng ZhouQiang Wang
Nov 20, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph L Dempsey, Julia Yue Cui
Apr 28, 2018·International Journal of Molecular Sciences·Weili YangJichun Yang
Nov 21, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jacques J FrigaultPier Jr Morin
Aug 10, 2019·Journal of Physiology and Biochemistry·Yanqiu HuangAiying Zhao
Aug 19, 2018·Journal of Translational Medicine·Chin-An YangCarmen Scheibenbogen
Feb 24, 2020·BMC Pulmonary Medicine·Nan QiuYingying He
Jan 26, 2021·Briefings in Functional Genomics·Partha ChattopadhyayRajesh Pandey
May 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan XuWei Zhang
Mar 5, 2021·Drug Delivery and Translational Research·Margarida Ferreira-SilvaMaria Luísa Corvo
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nutthapoom Pathomthongtaweechai, Somchai Chutipongtanate
May 23, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuxiao LiaoWei Yang
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haifang ZhangLijuan Zhang
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chan-Na ZhaoHai-Feng Pan
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiyuan Liang, Chunfeng Ren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis