Overexpression of the LSAMP and TUSC7 genes in acute myeloid leukemia following microdeletion/duplication of chromosome 3

Cancer Genetics
Nicoletta CoccaroFrancesco Albano

Abstract

The 3q13.31 microdeletion syndrome is characterized by developmental delay, postnatal growth above the mean, characteristic facial features, and abnormal male genitalia. Moreover, a frequent deletion in the 3q13.31 chromosome region has been identified in patients who are affected by osteosarcomas. Among the genes located within the deleted region, the involvement of the limbic system-associated membrane protein gene (LSAMP), together with a non-coding RNA tumor suppressor candidate 7 gene (TUSC7), has been suggested. We describe the case of an adult acute myeloid leukemia (AML) patient with a novel chromosomal rearrangement characterized by a 3q13.31 microdeletion and an extra copy of the 3q13.31-q29 chromosomal region translocated to the long arm of the Y chromosome. This karyotypic aberration seems to cause LSAMP and TUSC7 gene expression dysregulation. In conclusion, we report the first case of LSAMP and TUSC7 gene overexpression, possibly due to a position effect in an AML patient bearing a 3q13.31 cryptic deletion.

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Citations

Apr 29, 2016·Briefings in Functional Genomics·Mojdeh Nasrollahzadeh-KhakianiParvaneh Nikpour
Feb 18, 2017·Frontiers in Neuroscience·Taavi VanaveskiEero Vasar
Jul 26, 2021·Journal of Experimental & Clinical Cancer Research : CR·Krishnapriya M VarierBabu Gajendran

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