Overexpression of the MDM2 oncogene in leukemia and lymphoma

Leukemia & Lymphoma
T WatanabeT Hotta

Abstract

A cellular phosphoprotein that binds to and inactivates p53 has recently been identified as a product of the oncogene MDM2. Amplification of the MDM2 gene was found in more than a third of sarcomas and in a subset of malignant gliomas. Despite the absence of amplification, the MDM2 gene was overexpressed in some types of leukemias and lymphomas. Overexpression was significantly more frequent in the low-grade type of B-cell non-Hodgkin's lymphoma (B-NHL) than in the intermediate/high grade types of lymphoma and the overexpression was also significantly more frequent in the advanced rather than the earlier stages of B-cell chronic lymphocytic leukemia (B-CLL) and B-NHL. This suggests that MDM2 could play a role, via the p53 pathway, in tumorigenicity and/or in disease progression in some hematological malignancies. However, in the light of our findings that, in a few cases, both the overexpression of MDM2 and mutant-type p53 was seen, it is possible that MDM2 overexpression may also promote neoplastic growth by mechanisms other than inactivation of the p53 protein.

References

Mar 15, 1979·Nature·D P Lane, L V Crawford
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G GaidanoR Dalla-Favera
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M C HollsteinC C Harris
Oct 27, 1989·Science·T TakahashiJ D Minna
May 1, 1987·Somatic Cell and Molecular Genetics·L Cahilly-SnyderD L George
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LoveringP S Freemont
Jul 1, 1993·Molecular and Cellular Biology·J ChenA J Levine
Oct 1, 1994·British Journal of Haematology·B QuesnelP Fenaux
Nov 1, 1994·Molecular and Cellular Biology·V MarechalA J Levine
Sep 7, 1994·Journal of the National Cancer Institute·V A FlørenesO Fodstad
Sep 7, 1994·Journal of the National Cancer Institute·P LianesC Cordon-Cardo
Sep 7, 1994·Journal of the National Cancer Institute·T HabuchiO Yoshida
Oct 1, 1994·American Journal of Hematology·Y Q HuangA E Friedman-Kien
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Y ChenM B Kastan
Feb 1, 1994·British Journal of Haematology·S A RidgeL M Wiedemann
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M E PerryA J Levine
Jul 1, 1993·Genes & Development·X WuA J Levine
Jul 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G P Zambetti, A J Levine

❮ Previous
Next ❯

Citations

Aug 1, 1997·Cancer·M BenekliI C Haznedaroglu
Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·H SietsmaW Nijhof
Feb 4, 2012·Cell Death and Differentiation·M W Gramling, C M Eischen
Sep 18, 2002·The Journal of Experimental Medicine·Alex I ZaikaUte M Moll
Jul 22, 1998·Nucleic Acids Research·J MomandJ Niland
Oct 20, 2000·American Journal of Clinical Oncology·J A BogartC T Chung
Jan 23, 1999·Current Opinion in Oncology·M L Varterasian
Nov 16, 2004·Journal of Pediatric Hematology/oncology·Sara StonehamUNKNOWN United Kingdom Children's Cancer Study Group
Jun 11, 2008·Molecular and Cellular Biology·Alyssa BouskaChristine M Eischen
Nov 15, 2012·Genes & Cancer·Maurisa F Riley, Guillermina Lozano
Jan 15, 2005·Blood·Irene M GhobrialThomas E Witzig
May 19, 2006·American Journal of Clinical Pathology·Matthieu Bui Nguyen BinhJean-Michel Coindre
Mar 4, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Beng Hooi PhangKanaga Sabapathy
Nov 6, 2007·Cancer Genetics and Cytogenetics·Onoshua LahiriMelanie Howell
Jul 18, 2015·Environmental Research·Ryan ClantonGamal Akabani
Dec 21, 2004·Leukemia Research·Xinwei ZhangJianxiang Wang
Aug 16, 2016·Biochemical and Biophysical Research Communications·Dong Min KimIl-Chul Kim
Dec 18, 1998·Science·P SunD Beach
Jul 27, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·I A AtencioK N Wills
Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Dana ThomasovaHans-Joachim Anders
Jun 29, 2006·The Journal of Biological Chemistry·Mu-Shui DaiHua Lu
Jul 31, 2013·Acta Crystallographica. Section D, Biological Crystallography·Burcu AnilMartin E M Noble
Jan 16, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Troy R ShirangiUte M Moll
Aug 29, 2017·Expert Opinion on Investigational Drugs·Christian KleinGünter Fingerle-Rowson
Jan 8, 2020·International Journal of Molecular Sciences·Scott BangManabu Kurokawa
Mar 1, 2005·The Journal of Biological Chemistry·Jodi R AltChristine M Eischen
May 27, 2020·Nucleic Acids Research·Sivakumar Vadivel GnanasundramRobin Fåhraeus
Aug 17, 2005·Cancer Research·Levi J BeverlyAnthony J Capobianco
Feb 27, 2009·Cancer Research·Alyssa Bouska, Christine M Eischen
Mar 15, 2020·Molecular Cancer Research : MCR·Iris KamerJair Bar

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.