Overexpression of the PRAD1 oncogene in a patient with multiple myeloma and t(11;14)(q13;q32)

Acta Haematologica
H KobayashiT Motokura

Abstract

The t(11;14)(q13;q32) chromosomal translocation is associated with several B-cell lymphoproliferative disorders and is thought to result in upregulation of expression of PRAD1/cyclin D1 proto-oncogene. A patient with multiple myeloma of IgG kappa-type with t(11;14)(q13;q32) is now shown to overexpress PRAD1. The clinical stage of the disease was advanced (IIIA), with a myeloma cell count of 94.6% in the bone marrow. Chromosomal analysis of bone marrow cells showed t(11;14)(q13;q32) in five of 20 metaphases as well as other karyotypic features. Northern blot analysis of RNA prepared from myeloma cells revealed overexpression of PRAD1. Multiple myeloma with t(11;14)(q13;q32) has been associated with an aggressive clinical course. Although neither myeloma cells in the peripheral blood nor extramedullary lesions were apparent in the present patient, the myeloma was refractory to several chemotherapeutic regimens from the beginning. Detection of PRAD1 expression may offer an easier alternative to cytogenetic analysis in myeloma and is a potentially useful indicator of a poor prognosis.

Citations

Jun 3, 1998·British Journal of Haematology·R FonsecaP R Greipp
Dec 28, 1999·Leukemia & Lymphoma·R FonsecaP R Greipp
Nov 13, 2007·Hematology/oncology Clinics of North America·Giovanni Tonon
Feb 1, 1997·Hematology/oncology Clinics of North America·R FeinmanG Tricot
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·E AthanasiouC S Papadimitriou
Dec 6, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G KastrinakisC Kittas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Cancer Genetics and Cytogenetics
P MeeusH Van den Berghe
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
H J WehD K Hossfeld
British Journal of Haematology
C PreudhommeP Fenaux
© 2021 Meta ULC. All rights reserved