Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer

International Journal of Oncology
Taiki MasudaKenichi Sugihara

Abstract

We aimed to identify a novel prognostic biomarker related to recurrence in stage II and III colorectal cancer (CRC) patients. Stage II and III CRC tissue mRNA expression was profiled using an Affymetrix Gene Chip, and copy number profiles of 125 patients were generated using an Affymetrix 250K Sty array. Genes showing both upregulated expression and copy number gains in cases involving recurrence were extracted as candidate biomarkers. The protein expression of the candidate gene was assessed using immunohistochemical staining of tissue from 161 patients. The relationship between protein expression and clinicopathological features was also examined. We identified 9 candidate genes related to recurrence of stage II and III CRC, whose mRNA expression was significantly higher in CRC than in normal tissue. Of these proteins, the S100 calcium-binding protein A2 (S100A2) has been observed in several human cancers. S100A2 protein overexpression in CRC cells was associated with significantly worse overall survival and relapse-free survival, indicating that S100A2 is an independent risk factor for stage II and III CRC recurrence. S100A2 overexpression in cancer cells could be a biomarker of poor prognosis in stage II and III CRC recurre...Continue Reading

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Citations

Aug 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chen LiHongchang Gao
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Datasets Mentioned

BETA
GSE64257
GSE64258

Methods Mentioned

BETA
chromosomal aberrations
PCR

Software Mentioned

Chromosome Copy Number Analysis Tool (
R
BioConductor
SPSS
Relative Quantification Study Sequence Detection System
Affymetrix )

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