Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma

Cancer Science
Y OjiH Sugiyama

Abstract

The expression of the Wilms' tumor gene WT1 was examined by immunohistochemistry in 40 cases of pancreatic ductal adenocarcinoma. WT1 protein was expressed in 30 (75%) of the 40 pancreatic ductal adenocarcinomas, but not in the remaining 10 (25%). In normal pancreatic ductal cells, WT1 protein was undetectable. No correlations between WT1 expression and clinicopathological parameters such as age, sex, T or N stage, tumor location, and tumor differentiation were observed. Treatment with WT1 antisense oligomers significantly inhibited the growth of five human pancreatic cancer cell lines, PSN1, MiaPaCa2, ASPC1, BxPC3, and PCI6, expressing the WT1 gene. These results indicate an important role of the WT1 gene in the tumorigenesis of pancreatic ductal adenocarcinoma expressing WT1 and provide a rationale for new treatment strategies to treat pancreatic ductal adenocarcinoma by targeting the WT1 gene and its product.

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Citations

May 28, 2005·Leukemia·U KeilholzH Sugiyama
Aug 11, 2007·Leukemia·W GlienkeL Bergmann
Apr 17, 2010·Japanese Journal of Clinical Oncology·Haruo Sugiyama
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Dec 30, 2015·Molecular Carcinogenesis·Nozomi HojoYusuke Oji
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Apr 23, 2009·International Journal of Cancer. Journal International Du Cancer·Yusuke OjiHaruo Sugiyama
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