Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome.

Oncology Reports
Agnieszka RybarczykPiotr M Wierzbicki

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC (70-80%). Yes-associated protein 1 (YAP1) protein is a nuclear effector of the Hippo pathway and acts as a transcriptional co-activator of genes involved in the processes of growth and development of tissues. Hippo signaling, with its key kinases, MST2 and large tumor suppressor kinase 1 (LATS1), plays a significant role in the negative regulation of the amount and activity of YAP1 protein. Components of the Hippo pathway and YAP1 levels are frequently dysregulated in a variety of tumors, suggestive of their possible involvement in carcinogenesis. Our aim was to evaluate gene and protein expression profiles of YAP1, MST2 and LATS1 and the methylation status of MST2 and LATS1 promoters in ccRCC. mRNA levels of MST2, LATS1 and YAP1 genes were assessed in the tumor and matched normal kidney tissues of 86 patients, and in 12 samples of local metastases by quantitative PCR (qPCR). Proteins were semi-quantified in 58 patient samples by western blotting. Hypermethylation of LATS1 and MST2 promoters was measured by methylation‑specific high‑resolution-melting qPCR. We found that LATS1 promoter hypermethylation, decreased LATS1 mRNA/protein and increased YAP1 mRNA...Continue Reading

References

Jan 16, 2007·The Journal of Urology·Giacomo NovaraVincenzo Ficarra
Jun 1, 2007·Molecular Carcinogenesis·Claudia SeidelReinhard Dammann
Jul 12, 2007·Nature Reviews. Molecular Cell Biology·Leslie J Saucedo, Bruce A Edgar
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Oct 29, 2008·Current Opinion in Cell Biology·Bin ZhaoKun-Liang Guan
May 5, 2010·Genes & Development·Bin ZhaoKun-Liang Guan
Dec 9, 2010·Development·Georg Halder, Randy L Johnson
Jul 1, 2011·The American Journal of Surgical Pathology·Brett DelahuntJohn R Srigley
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dawang ZhouJoseph Avruch
Feb 18, 2012·The Journal of Biological Chemistry·Wesley M KonsavageGregory S Yochum
Mar 1, 2010·Oncology Letters·Hidefumi SasakiYoshitaka Fujii
Mar 8, 2013·Nature Reviews. Cancer·Kieran F HarveyDavid M Thomas
Jul 26, 2013·World Journal of Gastroenterology : WJG·Piotr M WierzbickiZbigniew Kmiec
Aug 21, 2013·Cellular Oncology (Dordrecht)·Eva J VlugPatrick W B Derksen
Dec 11, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yasmine TouilGuillemette Huet
Dec 18, 2013·Nature Reviews. Drug Discovery·Randy Johnson, Georg Halder
Apr 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xu-Yong LinEn-Hua Wang
Jul 1, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Kun LiangCuiping Zhang
Jul 6, 2014·Oral Oncology·Fredrik JerhammarKarin Roberg
Jul 10, 2014·Folia Histochemica Et Cytobiologica·Elena-Roxana AvădăneiIrina-Draga Căruntu
Sep 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Piotr M WierzbickiZbigniew Kmiec
Oct 8, 2014·Physiological Reviews·Stefano PiccoloMichelangelo Cordenonsi
Nov 13, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Keun-Wook LeeJu-Seog Lee
Dec 3, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Johannes C van der MijnHenk M Verheul
Jan 30, 2015·International Journal of Cancer. Journal International Du Cancer·Hua YuanQingyi Wei
Feb 11, 2015·Trends in Biochemical Sciences·Sonali J Rawat, Jonathan Chernoff
Feb 24, 2015·Trends in Molecular Medicine·Steven W PlouffeKun-Liang Guan
Mar 6, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shumei SongJaffer A Ajani
Mar 7, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Vijaya Ramakrishna ReddyArvind Ramanathan
Mar 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong-Chang Liu, Yan-zhou Wang
Mar 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Daniel KeizmanRaanan Berger
Mar 19, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cong DongLei Zhang
Apr 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Akihiko MiyanagaTesshi Yamada
Jul 15, 2015·Folia Histochemica Et Cytobiologica·Piotr M Wierzbicki, Agnieszka Rybarczyk

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Citations

Mar 5, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Barry J Thompson
Nov 23, 2018·International Journal of Molecular Sciences·Satoshi NoguchiTakahide Nagase
Sep 15, 2020·Journal of Biochemical and Molecular Toxicology·Shan XuPengsheng Zheng
Aug 9, 2019·Journal of Experimental & Clinical Cancer Research : CR·Lei YinBo Peng
Dec 1, 2020·Cellular Signalling·Priyanka SamjiKarunagaran Devarajan
Feb 25, 2021·Journal of Experimental & Clinical Cancer Research : CR·Balawant KumarAmar B Singh
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lu XuHongying Zhao

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