Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer.

Oncotarget
Christoph BurdelskiStefan Steurer

Abstract

Thymidylate synthase (TYMS) plays a role in DNA synthesis and is a target for 5-fluorouracil. In this study TYMS was analyzed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers. TYMS expression was higher in neoplastic than in normal prostate epithelium and was detectable in 72.9% of 10,223 interpretable cancers. It was considered strong in 21.9%, moderate in 33.4% and weak in 17.6% of tumors. TYMS overexpression was associated with deletions at 5q21 (p < 0.0001), 6q15 (p < 0.0001) and 3p13 (p = 0.0083) and gradually increased with the total number of these deletions present in the respective cancer sample (p < 0.0001). TYMS expression was unrelated to PTEN deletions (p = 0.9535) but tightly linked to high Gleason grade, advanced pathological tumor stage and early PSA recurrence (p < 0.0001). The prognostic value of TYMS was independent from the ERG status and deletions at 3p13, 5q21, and 6q15. In multivariate analyses the prognostic role of TYMS expression was independent of Gleason grade, pT stage, preoperative PSA, pN stage, or resection margins. TYMS expression analysis might result in clinically useful information in prostate cancer. The striking link to some but not all chromosomal aberratio...Continue Reading

References

Feb 1, 1986·The Journal of Infectious Diseases·M ResnickL Levy
Jan 1, 1995·Annual Review of Biochemistry·C W Carreras, D V Santi
May 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B C PestalozziP G Johnston
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
May 2, 2003·Nature Reviews. Cancer·Daniel B LongleyPatrick G Johnston
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sanjay PopatRichard S Houlston
Apr 20, 2004·Cancer Cell·Lambratu RahmanMaria Zajac-Kaye
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Youcef M Rustum
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Sep 19, 2007·Cancer Research·Jacques LapointeJonathan R Pollack
Jun 17, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thorsten SchlommAndreas Erbersdobler
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander T El GammalThorsten Schlomm
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah MinnerThorsten Schlomm
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Fanny LeméeChristophe Cazaux
Feb 11, 2011·Nature·Michael F BergerLevi A Garraway
Jul 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah MinnerThorsten Schlomm
Feb 2, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Martina KluthSarah Minner
Mar 16, 2013·Cancer Research·Lia BurkhardtRonald Simon
Jan 15, 2014·Cancer Research·Venkatadri KollaGarrett M Brodeur
Apr 8, 2014·Cell Reports·Xiang ChenUNKNOWN St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
Apr 30, 2014·Annual Review of Biophysics·Helen Walden, Andrew J Deans

❮ Previous
Next ❯

Citations

Dec 1, 2015·Future Oncology·Nataliya Uboha, Howard S Hochster
Nov 1, 2017·World Journal of Gastroenterology : WJG·Diego MarquesVivian Nogueira Silbiger
Nov 28, 2019·Molecular and Cellular Biochemistry·Aymen ShatnawiEfrosini Tsouko
Aug 1, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Wan-Liang GuoJian Wang
Nov 17, 2019·International Journal of Cancer. Journal International Du Cancer·Julia S GerkeThomas G P Grünewald
Oct 9, 2020·Clinical and Experimental Pharmacology & Physiology·Shaoran SongJuan Li
Aug 25, 2020·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Ragaa A RamadanMohamed Shamesya
Apr 4, 2020·Molecular Metabolism·Aarif Siddiqui, Paolo Ceppi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
chromosomal aberrations
biopsies

Software Mentioned

JPM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P Savage, J Waxman
JAMA : the Journal of the American Medical Association
A S Robbins
BMJ : British Medical Journal
Timothy J Wilt, Philipp Dahm
Biochemical Society Transactions
M P IqbalM Ahmed
© 2021 Meta ULC. All rights reserved