Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer

Annals of Surgical Oncology
Shoichiro MukaiWataru Yasui

Abstract

Gastrointestinal (GI) cancer, including gastric cancer (GC), colorectal cancer (CRC), and esophageal squamous cell carcinoma (ESCC), is the most common malignancy worldwide. To identify genes that encode transmembrane proteins present in GI cancer, Escherichia coli ampicillin secretion trap libraries were generated from MKN-74 GC cells, and BST2 was identified as overexpressed in GC. This study analyzed the expression and function of the BST2 gene in human GI cancers and examined the relationship between bone marrow stromal antigen-2 (BST-2) expression and GI patient clinicopathologic characteristics. Expression and distribution of BST-2 protein was analyzed by immunohistochemistry in 180 GC cases, 140 CRC cases, and 132 ESCC cases. Cell growth was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Immunohistochemical analysis of BST-2 in GC tissues showed that 65 (36 %) of 180 GC cases were positive for BST-2. Uni- and multivariate analyses demonstrated that BST-2 expression is an independent prognostic classifier of GC patients. Immunohistochemical analysis showed that 46 % of 140 CRC cases and 27 % of 132 ESCC cases were positive for BST-2. In ESCC, BST-2 expression was an independent progn...Continue Reading

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Citations

May 19, 2018·Biotechnology Letters·Weiyu LiuChangqing Zheng
Apr 15, 2018·Biological Research·Chunsheng LiWei Yu
Jun 16, 2017·Cell Death & Disease·Chun-Mei KuangRan-Yi Liu
Jan 5, 2017·Nature·Noah D Peyser, Jennifer R Grandis
Jul 13, 2019·Journal of Cellular Biochemistry·Xi ChenEnjian Shen
Apr 8, 2020·Experimental and Therapeutic Medicine·Hui ZhangJifeng Feng
Jul 23, 2016·Journal of Experimental & Clinical Cancer Research : CR·Xin LiXiaochun Wan
Apr 14, 2019·International Journal of Clinical Oncology·Naohide OueWataru Yasui
Dec 6, 2018·Scientific Reports·Wadie D Mahauad-FernandezChioma M Okeoma
Mar 21, 2019·Cancer Research·Guizhong ZhangXiaochun Wan
May 14, 2020·Neoplasia : an International Journal for Oncology Research·Daniel J ColemanJoshi J Alumkal
Jun 22, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Yuji YamamotoWataru Yasui

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