Overexpression of tumor necrosis factor (TNF)alpha and TNFalpha receptor I in human viral myocarditis: clinicopathologic correlations

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Fiorella CalabreseGaetano Thiene

Abstract

Proinflammatory cytokines, including tumor necrosis factor (TNF)alpha, have been recognized as important physiopathogenetic factors in the initiation and continuation of inflammatory cardiomyopathies. Experimental and preliminary human studies have demonstrated that TNFalpha plays a crucial role in enteroviral-induced myocarditis. In this study, we investigated the expression of TNFalpha and both its receptors (TNFRI and TNFRII) in both viral and nonviral myocarditis. Myocardial expression of TNFalpha was then correlated with different clinical and pathologic findings. TNFalpha expression was investigated in endomyocardial biopsies obtained from 38 patients with myocarditis and from eight control subjects by using reverse transcriptase-polymerase chain reaction (PCR) and immunohistochemistry. Viral etiology was diagnosed by PCR in 20 cases: enterovirus in seven, Epstein-Barr virus in four, hepatitis C virus in three, adenovirus in two, influenza virus in two, cytomegalovirus in one, and double infection adenovirus and enterovirus in one. Immunohistochemistry was also used to analyze both TNFalpha receptors (RI and RII). A semiquantitative analysis was employed (score 0-3) for necrosis, inflammation, fibrosis and immunohistochem...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·P Vassalli
Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Jun 1, 1987·Human Pathology·H T Aretz
Jun 1, 1986·Postgraduate Medical Journal·M E Billingham, H D Tazelaar
Apr 1, 1974·Lancet·P J Richardson
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
Jul 1, 1994·Circulation·A B MartinJ Ni
Apr 29, 1994·Science·B Beutler, C van Huffel
May 1, 1994·Circulation·W H Barry
Apr 1, 1993·The Journal of General Virology·J S GillespieP O Behan
Aug 1, 1993·Clinical Immunology and Immunopathology·D A NeumannN R Rose
May 1, 1996·Current Opinion in Cardiology·A Matsumori
Mar 7, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·T JibikiH Niimi
Mar 15, 2000·Journal of the American College of Cardiology·A M FeldmanC McTiernan
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G NigroS P Adler
Oct 12, 2000·Journal of the American College of Cardiology·M SatohK Hiramori
Aug 29, 2001·Circulation·P P Liu, J W Mason
Sep 11, 2001·Journal of Molecular and Cellular Cardiology·B GlückD Gemsa
Dec 3, 2002·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Fiorella CalabreseGaetano Thiene

❮ Previous
Next ❯

Citations

Oct 6, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xingsan TangJihua Dong
Apr 16, 2010·Journal of Clinical Microbiology·Simona PuzelliUNKNOWN Campania H1N1 Task Force
Jun 22, 2013·BMC Infectious Diseases·Guo-Shiang TsengJenq-Shyong Chan
Oct 29, 2010·Virology Journal·Song ZhangGeorge Ruiz
Jul 1, 2010·American Journal of Clinical Dermatology·Brian Berman
Sep 1, 2005·Future Cardiology·Akira Matsumori
Jul 31, 2013·Journal of Zhejiang University. Science. B·Li-na HanTing Zhang
May 1, 2010·The Journal of Infection·Ismail ErdenTalha Dumlu
Mar 26, 2005·Immunology Letters·José Manuel Rodríguez-PérezGilberto Vargas-Alarcón
May 21, 2011·Circulation Research·Christoph LeibZiya Kaya
Feb 16, 2006·Circulation·Jared W Magnani, G William Dec
Dec 18, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ya-Nan ZhaoPing Yang
Jun 12, 2013·Virchows Archiv : an International Journal of Pathology·Gaetano ThieneOrnella Leone
Jul 27, 2017·Influenza and Other Respiratory Viruses·Subhashini A SellersWilliam A Fischer
Jan 11, 2020·Critical Care Medicine·Chang GaoUNKNOWN for the Community-Acquired Pneumonia–China Network
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chanatip OoppachaiSupachai Yodkeeree
Mar 25, 2020·Critical Care Medicine·Chang GaoUNKNOWN Community-Acquired Pneumonia–China Network
Nov 25, 2019·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Dana Razzano, John T Fallon
Sep 23, 2019·Médecine et maladies infectieuses·S Bessis, M Matt
Jan 15, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Fiorella CalabreseGaetano Thiene

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.