Overexpression of tyrosine kinase B protein as a predictor for distant metastases and prognosis in gastric carcinoma

Oncology
Yong ZhangMorito Monden

Abstract

Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). We analyzed TrkB expression in 161 GC patients by immunohistochemistry and Western blot analysis. The correlation of TrkB mRNA and protein expression levels was examined in 10 patients by RT-PCR assay. TrkB expression was of level 1 in 97 (60.2%) and level 2 in 64 (39.8%) patients. Patients with level 2 expression had a significantly higher incidence of distant metastases (p < 0.0001), well-differentiated tumors (p < 0.005), deeper depth of invasion (p < 0.005) and poorer disease-free and overall survival (p < 0.0001 each) compared to patients with level 1. Multivariate analysis identified the level of TrkB expression as an independent prognostic factor for both disease-free and overall survival (p < 0.01 and p < 0.0001, respectively). Both lymph node metastasis (odds ratio = 10.7) and TrkB expression (odds ratio = 9.3) were independent predictors of distant metastases. A high level of TrkB expression was observed in well-differentiated GC subtypes and is a predictor for distant metastases and prognosis in GC.

Citations

Sep 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carol J ThieleAmy E McKee
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Lokesh Dalasanur NagaprashanthaSharad S Singhal
Feb 6, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yingjiao YuGuocheng Ou
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Xiangming Guan
Jul 9, 2013·Biochimica Et Biophysica Acta·Paolo PaoliPaola Chiarugi
Aug 22, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kyoko OkamuraYoichi Nakanishi
Nov 5, 2016·International Journal of Oral and Maxillofacial Surgery·L Li, L Zhu
Feb 12, 2019·Cell Death & Disease·Sabrina BlondyAurélie Perraud
Aug 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ali Mohammad AlizadehSadaf Farsinejad
Aug 12, 2020·Cancer Metastasis Reviews·Leela Rani AvulaChristine Alewine
Apr 12, 2012·Experimental Biology and Medicine·Yujing YinHong Zhou
May 16, 2019·Revista do Colégio Brasileiro de Cirurgiões·Bruno Pereira AntunesCarlos Roberto Galia
Oct 16, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A KamiyaK Kojima
Dec 4, 2013·Oncology Reports·Shi-Sheng LiXin-Ming Yang
Jun 3, 2021·Journal of Clinical Medicine·Monika PrillMariusz R Wieckowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.