Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma

Thoracic Cancer
Baozhu ZhangYing-Hui Zhu

Abstract

Ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). USP14 expression was detected in ESCC tissues and matched adjacent non-tumorous tissues by quantitative real-time reverse transcription-PCR and immunohistochemistry. Kaplan-Meier survival analysis was used to assess the correlation between USP14 expression and prognosis in ESCC patients. Univariate and multivariate analysis was conducted with a Cox proportional hazards model to determine whether USP14 is an independent prognostic factor. Overexpression of USP14 was observed in approximately 60% of tested ESCC samples compared to their paired non-tumor esophageal tissues at both RNA and protein levels, and was significantly associated with distant metastasis (P = 0.001). Kaplan-Meier analysis showed that USP14 overexpression was related to poorer overall patient survival. Univariate and multivariate analyses demonstrated that USP14 was an independent risk factor for overall survival. The findi...Continue Reading

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Citations

Nov 7, 2019·Journal of Experimental & Clinical Cancer Research : CR·Liling JiangJinbao Liu
May 21, 2020·International Journal of Molecular Sciences·Nair LopesCarmen Jerónimo
Mar 7, 2020·Signal Transduction and Targeted Therapy·Lu DengPing Wang
Jul 31, 2020·International Journal of Molecular Sciences·Ji Yeong ShinByung-Hoon Lee
Jul 26, 2019·Apoptosis : an International Journal on Programmed Cell Death·Beibei ShaPei Li
Feb 19, 2020·Chemical Communications : Chem Comm·Yan-Yan LiangHuai-Song Wang
Aug 27, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Ji ChengWenyi Wei
Nov 3, 2020·Journal of Cellular Physiology·Dan WangJing Zhao
Apr 17, 2020·Signal Transduction and Targeted Therapy·Lu DengPing Wang
Jul 3, 2021·International Journal of Molecular Sciences·Seonghyeon MoonByung-Hoon Lee

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Datasets Mentioned

BETA
KYSE520

Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS

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