Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF.

Journal of Cellular and Molecular Medicine
Xiao-Yong ManMin Zheng

Abstract

Psoriasis is a common chronic inflammatory disease of the skin characterized by epidermal hyperplasia and angiogenesis. Recently, vascular endothelial growth factor receptors (VEGFRs, including VEGFR-1, VEGFR-2 and VEGFR-3) were found to be expressed in normal human epidermis and associated with proliferation and migration of keratinocytes. The purpose of this study is to investigate the expression of VEGFRs on psoriatic keratinocytes and the roles of calcium and VEGF in regulating VEGFR expression. Skin samples from 17 patients with chronic plaque psoriasis and 11 normal controls were included. The expression of VEGFRs in psoriatic keratinocytes at mRNA and protein levels was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis. Localization of the VEGFRs in skin lesions was determined by immuno-fluorescent method. Since keratinocyte proliferation and differentiation rely on calcium concentrations, and VEGF is overexpressed in psoriatic epidermis, we further investigated the roles of calcium and VEGF in regulating the expression of VEGFRs. Overexpression of VEGFR-1, VEGFR-2 and VEGFR-3 in psoriatic epidermis was demonstrated both at mRNA and protein levels in vitro. VEGFRs were stron...Continue Reading

References

Mar 1, 1985·The Journal of Investigative Dermatology·J A FairleyJ J Voorhees
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KaipainenK Alitalo
May 27, 1999·Seminars in Cancer Biology·T Veikkola, K Alitalo
Jan 5, 2000·The Journal of Biological Chemistry·B V DiazS Michel
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T A PartanenK Alitalo
Feb 14, 2004·The Journal of Investigative Dermatology·Helen S YoungChristopher E M Griffiths
Feb 14, 2004·The Journal of Investigative Dermatology·Michael Detmar
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Jan 7, 2005·Nature Medicine·Mark R Pittelkow
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Xue-Feng WangJoanne A Matsubara
May 6, 2005·The New England Journal of Medicine·Michael P Schön, W-Henning Boehncke
Sep 3, 2005·Nature Reviews. Immunology·Anne M Bowcock, James G Krueger
Oct 28, 2005·The American Journal of Pathology·Traci A WilgusLuisa A DiPietro
Feb 4, 2006·Current Pharmaceutical Design·Adela R Cardones, Lionel L Banez
Aug 26, 2006·Biochemical and Biophysical Research Communications·Xiao-Hong YangMin Zheng
Mar 7, 2007·Journal of Clinical Immunology·Jozélio Freire CarvalhoYehuda Shoenfeld

❮ Previous
Next ❯

Citations

Jan 4, 2013·Cell Biochemistry and Biophysics·Jia-Qi ChenMin Zheng
May 6, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shokoufeh Shahrabi-FarahaniDiane R Bielenberg
Jan 22, 2013·Cellular and Molecular Life Sciences : CMLS·Xiao-Yong ManMin Zheng
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Helia B SchonthalerErwin F Wagner
Sep 18, 2010·Leukemia & Lymphoma·Maria B KarpovaMirjana Urosevic-Maiwald
Jun 13, 2015·The Journal of Investigative Dermatology. Symposium Proceedings·Xiao-Yong Man, Min Zheng
Mar 17, 2012·Reumatología clinica·Carlos Montilla MoralesJavier Del Pino-Montes
Jun 30, 2010·Journal of the American Academy of Dermatology·Ricardo T PaniaguaWilliam H Robinson
Nov 21, 2009·Journal of the American Academy of Dermatology·Vivian LaquerKristen M Kelly
Mar 25, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A NofalA Abdalmoati
Mar 23, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·I FlisiakB Chodynicka
Jul 24, 2010·British Journal of Pharmacology·X ZhangJ E Groopman
Nov 9, 2011·The International Journal of Biochemistry & Cell Biology·Jian-Wei ZhuMin Zheng
Jun 2, 2016·Aesthetic Surgery Journal·Bong-Sung KimNorbert Pallua
May 8, 2016·The British Journal of Dermatology·J VegforsC Enerbäck
Nov 25, 2016·Nature Reviews. Disease Primers·Jacqueline E GrebAlice B Gottlieb
Dec 5, 2012·The Journal of International Medical Research·W Y MaQ Sun
Jan 17, 2015·Biomolecules & Therapeutics·Ok-Nam BaeTae Cheon Jeong
Jan 15, 2020·Science Advances·Farida BenhadouCédric Blanpain
Jul 13, 2020·Experimental Dermatology·Andrea Luengas-MartinezHelen S Young
Jun 18, 2018·Archives of Dermatological Research·Xian-Jie WuMin Zheng
Oct 30, 2009·Autoimmunity·Ramon Alvin Chua, Jack L Arbiser
Mar 20, 2020·Cell Systems·Alexander G GogliaJared E Toettcher
Jun 18, 2021·International Journal of Clinical Practice·Yıldız HayranTuran Turhan

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Software Mentioned

Gel
DNAstar package
- Pro Analyzer
PrimerSelect

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.