Abstract
Chronic myelogenous leukemia (CML) is a hematopoietic disorder, which begins as indolent chronic phase but inevitably progresses to fatal blast crisis. p210BCR/ABL, a constitutively active tyrosine kinase, is responsible for disease initiation but molecular mechanism(s) underlying disease evolution remains largely unknown. To explore this process, we employed retroviral insertional mutagenesis to CML-exhibiting p210BCR/ABL transgenic mice (Tg). Virus infection induced acute lymphoblastic leukemia (ALL) in p210BCR/ABL Tg with a higher frequency and in a shorter latency than wild-type littermates, and inverse PCR detected two retrovirus common integration sites (CISs) in p210BCR/ABL Tg tumors. Interestingly, one CIS was the transgene itself, where retrovirus integrations induced upregulation of p210BCR/ABL and production of truncated BCR/ABL with an enhanced kinase activity. Another CIS was Notch1 gene, where retrovirus integrations resulted in overexpression of Notch1 and generation of Notch1 lacking the C-terminal region (Notch1DeltaC) associated with stable expression of its activated product, C-terminal-truncated Notch intracellular domain (NICD Delta C). In addition, generation of Tg for both p210BCR/ABL and Notch1DeltaC dev...Continue Reading
References
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K M AbrahamR M Perlmutter
Aug 23, 1991·Cell·L W EllisenJ Sklar
Jun 1, 1973·Nature·J D Rowley
May 16, 1996·Biochimica Et Biophysica Acta·J Jonkers, A Berns
May 19, 1997·Biochemical and Biophysical Research Communications·H HondaH Hirai
May 4, 1999·The Journal of Experimental Medicine·S LiR A Van Etten
Dec 30, 1999·Nature Genetics·C S HuettnerD G Tenen
Dec 12, 2002·Oncogene·Fabrizio PaneFrancesco Salvatore
Mar 29, 2003·Journal of Virology·Linda WolffMiriam R Anver
Jul 12, 2003·Blood·Claudia S HuettnerDaniel G Tenen
Dec 19, 2003·Nucleic Acids Research·Keiko AkagiNeal G Copeland
Dec 19, 2003·Oncogene·Linda WolffChristine Perella
Feb 26, 2004·Blood·Bruno Calabretta, Danilo Perrotti
May 25, 2004·Nature Cell Biology·Sachiko KamakuraYukiko Gotoh
Aug 28, 2004·Blood·Steffen KoschmiederClaudia S Huettner
Oct 9, 2004·Science·Andrew P WengJon C Aster
Dec 22, 2004·The Journal of Experimental Medicine·Masaru NikiPier Paolo Pandolfi
Jan 15, 2005·Cancer Science·Takuro Nakamura
Feb 19, 2005·Nature Reviews. Cancer·Ruibao Ren
Sep 17, 2005·Blood·Jennifer O'NeilA Thomas Look
Nov 10, 2005·Blood·Michaela ScherrMatthias Eder
Nov 12, 2005·British Journal of Haematology·Namiko YamashitaYoshiaki Ito
Nov 12, 2005·Blood·Ying-Wei LinPeter D Aplan
Mar 9, 2006·Blood·Dan YeRobert L Ilaria
Apr 14, 2006·Nature Reviews. Cancer·Clemens GrabherA Thomas Look
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva MonsalveMaría José M Díaz-Guerra
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
Mar 27, 2007·Cell·Maria Xenia G Ilagan, Raphael Kopan
Citations
Jan 12, 2010·Oncogene·N YamasakiH Honda
Aug 5, 2008·The Journal of Clinical Investigation·Mark Y ChiangWarren S Pear
Dec 17, 2008·Hematology·Catriona H Jamieson
Feb 24, 2009·Blood·Kazuko MiyazakiHiroaki Honda
Mar 24, 2010·BMC Biotechnology·Dilyara ArslanovaWeiming Xia
Apr 16, 2013·FEBS Letters·Rio NishibeHiroaki Honda
Feb 9, 2011·Leukemia & Lymphoma·Nicholas J Donato, Luke F Peterson
Jun 5, 2012·Cellular Signalling·P F Seke EtetA H Nwabo Kamdje
May 13, 2009·Cancer Science·Akiko NagamachiHiroaki Honda
Dec 7, 2013·The Journal of Pathology·Sukanya SureshAlexandra E Irvine
Sep 14, 2013·Cancer Cell·Akiko NagamachiToshiya Inaba
Aug 26, 2015·The Journal of Experimental Medicine·George GiotopoulosBrian J P Huntly
Apr 24, 2015·Blood·Taeko WadaYusuke Furukawa
Jul 16, 2009·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Naoya UchidaTakashi Shimada
Feb 26, 2015·Journal of Cell Communication and Signaling·Sukanya Suresh, Alexandra E Irvine
Apr 8, 2015·PloS One·Abdullah AljedaiFarhatullah Syed
Apr 19, 2016·Cancer Science·Yasuyuki SeraHiroaki Honda