Overgrowth of the Hand and Upper Extremity and Associated Syndromes

The Journal of Hand Surgery
Brian I LabowJoseph Upton

Abstract

The family of overgrowth disorders affecting the hand and upper extremity constitutes a wide spectrum of clinical phenotypes. These conditions and malformations may be isolated to the upper limb or part of an underlying syndrome. When present, these conditions will challenge even the most experienced hand surgeon. Overlapping clinical presentations and a lack of insight into the fundamental pathogenesis that drives overgrowth in these conditions have created confusion in diagnosis and classification, and have also hampered treatment outcome research. In recent years, advances in molecular biology have identified genetic mutations within the affected tissues of overgrowth patients that appear to mediate these disorders. This may elucidate further understanding, classification, and treatment of these conditions. The purpose of this article is to discuss a range of overgrowth conditions, review some of the newer biological insights, and delineate the general treatment principles.

References

May 1, 1977·The Journal of Hand Surgery·V E Wood, A E Flatt
Nov 1, 1985·The Journal of Hand Surgery·K Tsuge
Oct 27, 2004·Apoptosis : an International Journal on Programmed Cell Death·M OsakiH Ito
May 27, 2005·Current Opinion in Genetics & Development·Laurence M BoonMiikka Vikkula
Mar 29, 2007·The British Journal of Dermatology·R Happle
Apr 24, 2008·Nature Clinical Practice. Oncology·Deborah J MarshGlenn M Marshall
Apr 22, 2009·Hand Clinics·Matthew J CartyJoseph Upton
Jul 29, 2011·The New England Journal of Medicine·Marjorie J LindhurstLeslie G Biesecker
Jun 5, 2012·American Journal of Human Genetics·Kyle C KurekMatthew L Warman
Oct 27, 2012·Human Molecular Genetics·Jonathan J RiosMarybeth Ezaki
Oct 29, 2013·The Journal of Hand Surgery·Jacob Bloom, Joseph Upton
Jan 1, 2014·Plastic and Reconstructive Surgery·Reid A MaclellanKyle C Kurek
May 2, 2014·American Journal of Medical Genetics. Part a·Kim M Keppler-NoreuilLeslie G Biesecker
Jun 7, 2014·American Journal of Medical Genetics. Part a·Ana S A CohenWilliam T Gibson
Sep 30, 2014·Seminars in Cell & Developmental Biology·Anurag Saxena, Julian R Sampson
Jan 6, 2015·American Journal of Medical Genetics. Part a·Kim M Keppler-NoreuilLeslie G Biesecker

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Citations

Sep 14, 2018·The Journal of Hand Surgery, European Volume·Marybeth EzakiScott N Oishi
May 10, 2020·The Journal of Hand Surgery, European Volume·Mohammed M Al-QattanSaeed Alsheiban
Feb 11, 2021·Plastic and Reconstructive Surgery. Global Open·Mohammad M Al-Qattan
Jan 2, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Wei ChenWei Huang
Nov 16, 2021·ELife·Kaylee M WellsCatherine D McCusker

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