Overhauser dynamic nuclear polarization amplification of NMR flow imaging

Journal of Magnetic Resonance
Mark D LingwoodSongi Han

Abstract

We describe the first study comparing the ability of phase shift velocity imaging and Overhauser dynamic nuclear polarization (DNP)-enhanced imaging to generate contrast for visualizing the flow of water. Prepolarization of water by the Overhauser DNP mechanism is performed in the 0.35T fringe field of an unshielded 2.0T non-clinical MRI magnet, followed by the rapid transfer of polarization-enhanced water to the 2.0T imaging location. This technique, previously named remotely enhanced liquids for image contrast (RELIC), produces a continuous flow of hyperpolarized water and gives up to an -8.2-fold enhanced signal within the image with respect to thermally polarized signal at 2.0T. Using flow through a cylindrical expansion phantom as a model system, spin-echo intensity images with DNP are compared to 3D phase shift velocity images to illustrate the complementary information available from the two techniques. The spin-echo intensity images enhanced with DNP show that the levels of enhancement provide an estimate of the transient propagation of flow, while the phase shift velocity images quantitatively measure the velocity of each imaging voxel. Phase shift velocity images acquired with and without DNP show that DNP weights vel...Continue Reading

References

Aug 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T J Mosher, M B Smith
Jan 1, 1982·Magnetic Resonance Imaging·P R Moran
Jan 20, 2004·Journal of Magnetic Resonance·Andrew J SedermanLynn F Gladden
Jul 18, 2006·Academic Radiology·Klaes Golman, J Stefan Petersson
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Evan R McCarneySongi Han
Jun 19, 2007·Antioxidants & Redox Signaling·Ken-ichiro MatsumotoMurali C Krishna
Sep 18, 2007·The Journal of Chemical Physics·Brandon D Armstrong, Songi Han
Jan 30, 2008·Journal of Magnetic Resonance·Brandon D ArmstrongSongi Han
Sep 8, 2011·Physical Chemistry Chemical Physics : PCCP·P J M van BentumA P M Kentgens
Jan 18, 2012·Journal of Magnetic Resonance·Jan G KrummenackerThomas F Prisner

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Citations

Apr 18, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maxim TerekhovLaura Maria Schreiber
Feb 2, 2013·Journal of Magnetic Resonance·Henk Van As, John van Duynhoven
Dec 25, 2012·Journal of Magnetic Resonance·Lynn F Gladden, Andrew J Sederman
Oct 16, 2016·Journal of Magnetic Resonance·Bernhard Blümich
Nov 29, 2013·Physical Chemistry Chemical Physics : PCCP·Deniz Sezer

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