Overlap syndrome of autoimmune chronic liver diseases: MRI findings

Journal of Magnetic Resonance Imaging : JMRI
W Brian HyslopRichard C Semelka

Abstract

To describe the MR findings of overlap syndromes of autoimmune chronic liver diseases. Review of clinical and radiological databases between March 2001 and July 2008 for patients with a clinical diagnosis and liver biopsy features compatible with overlap syndrome who had also undergone an abdominal MRI yielded 15 adult patients. MR features of overlap syndrome were reviewed by two radiologists by consensus. Two radiologists independently reviewed the studies in a blinded fashion for primary sclerosing cholangitis (PSC)-type or non-PSC-type features to assess interobserver agreement. PSC-type and non-PSC-type overlap syndrome had distinctive MR features. In the consensus review, all 12 patients with PSC-type overlap syndrome were correctly identified. Imaging findings included central macroregeneration (N = 9), peripheral atrophy (N = 7), biliary duct beading (N = 12), biliary dilation (N = 10), or a combination of all four findings (N = 7). The presence of any of the first three features had 100% specificity for a PSC-type overlap syndrome. Patients with non-PSC-type overlap (N = 3) showed relatively normal liver morphology (N = 3) and minimal biliary ductal dilatation in one patient. There was good interobserver agreement (kap...Continue Reading

References

Sep 1, 1991·AJR. American Journal of Roentgenology·C B MajoieP L Jansen
Jun 1, 1989·Radiology·E OutwaterM S Bankoff
Oct 1, 1996·Annals of Internal Medicine·A J Czaja
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O ChazouillèresR Poupon
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W LohseH P Dienes
Jun 1, 1999·AJR. American Journal of Roentgenology·K ItoR Blasbalg
Nov 4, 2000·Journal of Hepatology·H R van BuurenF P Vleggaar
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G V GregorioG Mieli-Vergani
Mar 27, 2001·AJR. American Journal of Roentgenology·J S WenzelE Molmenti
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Woodward, J Neuberger
Sep 18, 2001·Gut·Z Ben-Ari, A J Czaja
Nov 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ayman A AbdoSamuel S Lee
Nov 5, 2003·Clinics in Liver Disease·Raoul Poupon
May 10, 2005·Clinical Reviews in Allergy & Immunology·Christoph Schramm, Ansgar W Lohse
Jun 30, 2005·The American Journal of Gastroenterology·Annarosa FloreaniVincenzo Baldo
Aug 25, 2005·Radiology·Fatmir BilajRichard C Semelka
Sep 7, 2005·Seminars in Liver Disease·Ulrich Beuers, Christian Rust
Sep 9, 2005·European Journal of Gastroenterology & Hepatology·Jeremy G C Kingham, Atta Abbasi
Jul 4, 2007·Clinics in Liver Disease·Aijaz Ahmed, Emmet B Keeffe
Jan 18, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rupert AbdalianE Jenny Heathcote
Jun 6, 2008·World Journal of Gastroenterology : WJG·Christian Rust, Ulrich Beuers

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Citations

Jun 21, 2015·Revista de gastroenterología de México·O Aguilar-NájeraA Torre
Dec 22, 2016·Abdominal Radiology·Neera Malik, Sudhakar K Venkatesh

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