Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis with unusual initial presentation as fulminant hepatic failure

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
E KayacetinT Temuçin

Abstract

Autoimmune hepatitis and primary biliary cirrhosis are generally easy to discriminate on the basis of clinical, laboratory, and histological findings. The presence of anti-mitocondrial antibodies seropositivity and cholestatic clinical, laboratory, and/or histological features in patients with autoimmune hepatitis indicates the overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis. Fulminant hepatic failure is an unusual initial form of presentation of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome. We report the case of a 50-year-old woman with autoimmune hepatitis and primary biliary cirrhosis overlap syndrome who presented with fulminant hepatic failure. Fulminant hepatic failure has a high mortality rate and may require liver transplant. Our patient revealed a good response to corticosteroid and ursodeoxycholic acid therapy. It is important to identify and distinguish autoimmune hepatitis and variant syndromes from other forms of liver disease because of response to corticosteroid therapy.

References

May 1, 1986·Seminars in Liver Disease·J BernuauJ P Benhamou
Jul 1, 1986·Digestive Diseases and Sciences·R P KennyE R Dickson
Oct 1, 1996·Annals of Internal Medicine·A J Czaja
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O ChazouillèresR Poupon
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Czaja
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W LohseH P Dienes
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Woodward, J Neuberger
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Arndt VogelChristian P Strassburg
Dec 13, 2002·Reumatizam·Ginevra FioriMarco Matucci Cerinic
May 16, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A FloreaniM Guido

❮ Previous
Next ❯

Citations

May 20, 2009·World Journal of Gastroenterology : WJG·Albert J Czaja, Yusuf Bayraktar
Aug 23, 2008·Journal of Clinical Gastroenterology·Aldo J Montano-LozaAlbert J Czaja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Related Papers

The Journal of the Association of Physicians of India
S ArulprakashS Jeevan Kumar
World Journal of Gastroenterology : WJG
Christian Rust, Ulrich Beuers
Seminars in Liver Disease
Ulrich Beuers, Christian Rust
© 2022 Meta ULC. All rights reserved