Overlap syndromes in systemic sclerosis

Postȩpy dermatologii i alergologii
Ewa WieloszBożena Targońska-Stępniak

Abstract

It is known, that course of the disease differs between overlap syndromes (OS) and systemic sclerosis (SSc) group. To compare the prevalence of OS in limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous SSc (dcSSc) and to analyze the presence of different manifestations in the SSc and OS group. The study included 126 European Caucasian SSc patients (99 females and 27 males) hospitalized consecutively in the Department of Rheumatology and Connective Tissue Diseases. Patients fulfilled the American College of Rheumatology (ACR) classification criteria of SSc (57 - dcSSc and 69 - lcSSc). The study groups were determined according to the subtype of SSc, coexistence of other connective tissue diseases (CTDs), and incidence of clinical and serological manifestations. In our SSc study group, 28/126 patients (22%) were affected by more than one CTD. The prevalence of OS was significantly higher in the lcSSc group - 33% (23/69) compared to the dcSSc group - 8% (5/57). We found that mortality and digital ulcers were significantly higher, whereas kidney involvement and arthritis were significantly lower in the SSc group compared to the OS group. The prevalence of anti-topoisomerase I (a-Scl-70) was significantly higher, and ...Continue Reading

Citations

Jan 8, 2022·The Journal of Applied Laboratory Medicine·Jugnu KishoreMala Mahto

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Methods Mentioned

BETA
ELISA

Software Mentioned

EUROLINE Systemic Sclerosis Profile
Euroimmun
EUROLINE Scan

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