Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p

Molecular Microbiology
M T DoolinGeraldine Butler

Abstract

The yeast transcription factors Ace2p and Swi5p regulate the expression of several target genes involved in mating type switching, exit from mitosis and cell wall function. We describe the analysis of 12 novel targets, some regulated by Ace2p or Swi5p alone and some by both. We show that Ace2p is the major regulator of four genes (CTS1, YHR143W, SCW11 and YER124C). Expression of all four is inhibited by Swi5p. Like Cts1p and Scw11p, the two new Ace2p targets are associated with cell wall metabolism. Yhr143p is localized to the cell wall, and deletion affects cell separation and enhances pseudohyphal growth. Deleting YER124C also affects cell separation and sensitivity to drugs targeted against the cell wall. Expression of PIR1, YPL158C and YNL046W is dependent on Swi5p alone. In contrast, expression of YBR158W, YNL078W and YOR264W is minimized when both ace2 and swi5 are disrupted. We propose that, although Ace2p and Swi5p co-operate to induce the expression of a subset of genes, some functional divergence has occurred. This results in a delay in the expression of those genes predominantly regulated by Ace2p, compared with those predominantly regulated by Swi5p.

References

Jan 1, 1991·Molecular and Cellular Biology·G Butler, D J Thiele
Sep 1, 1994·Molecular Biology of the Cell·S J KronG R Fink
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R M Brazas, D J Stillman
Aug 1, 1995·Protein Science : a Publication of the Protein Society·A F NeuwaldC E Lawrence
Jul 1, 1996·Molecular and Cellular Biology·B KovacechT Schuster
Oct 1, 1996·Molecular and Cellular Biology·D KnappK Nasmyth
May 16, 1998·Molecular Biology of the Cell·B L AerneL H Johnston
Aug 14, 1998·Molecular Cell·R J ChoR W Davis
Jul 20, 1999·The Journal of Biological Chemistry·H J McBrideD J Stillman
Aug 25, 1999·Current Opinion in Microbiology·G J SmitsF M Klis
Nov 26, 1999·Nature·E M MarcotteD Eisenberg
Feb 26, 2000·Trends in Genetics : TIG·S Kruglyak, H Tang
Aug 30, 2000·Nature·Y ZhuC C Mundt

❮ Previous
Next ❯

Citations

Oct 13, 2009·Current Genetics·Edward DraperDavid E Stone
Aug 21, 2013·Current Genetics·R Teparić, Vladimir Mrsa
Mar 22, 2008·Molecular Genetics and Genomics : MGG·H Reynaldo López-MirabalMorten C Kielland-Brandt
Oct 1, 2003·Journal of Molecular Biology·Thomas MankeMartin Vingron
Dec 4, 2001·Current Opinion in Microbiology·D RuaS J Kron
Sep 12, 2006·Nature Structural & Molecular Biology·Robert WysockiStephen J Kron
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xin GuoAlexander J Hartemink
Sep 15, 2012·The Journal of Biological Chemistry·Jason AuldsMark E Schmitt
Oct 10, 2008·Molecular Biology of the Cell·Yunkyoung SongJeong-Yoon Kim
Jul 18, 2006·Bioinformatics·Yu-Hsiang ChangBor-Sen Chen
Jul 26, 2006·Bioinformatics·Yong WangLuonan Chen
Nov 25, 2003·Nucleic Acids Research·Nilanjana Banerjee, Michael Q Zhang
Mar 10, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas Schlitt, Alvis Brazma
May 1, 2012·Eukaryotic Cell·Sarah SaputoDamian J Krysan
Jun 11, 2005·Eukaryotic Cell·Warren P VothDavid J Stillman
Aug 31, 2006·Molecular and Cellular Biology·Kellie S Bickel, David R Morris
Jun 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Guillaume Lesage, Howard Bussey
Jul 16, 2011·Interdisciplinary Perspectives on Infectious Diseases·Jalil Y DaherRoy A Khalaf
Jul 25, 2009·BMC Genomics·Yadong WangYunlong Liu
Jul 31, 2013·BMC Systems Biology·Chao ChengMark Gerstein
Aug 4, 2004·Genome Biology·Mamoru KatoMichael Q Zhang
Dec 30, 2006·PLoS Computational Biology·Christopher E HartBarbara J Wold
Aug 2, 2007·PloS One·Emmanuel J ChangTerry Gaasterland
Aug 31, 2013·PloS One·Miriam LarssonStefan Björklund
Nov 27, 2008·Genetics·Michael A WhiteBarak A Cohen
Jan 24, 2014·Molecular Biology and Evolution·Patricia S SoriaAntonis Rokas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.