Overlapping Autoimmune Syndromes in Patients With Glial Fibrillary Acidic Protein Antibodies

Frontiers in Neurology
Xinguang YangCong Gao

Abstract

Glial fibrillary acidic protein (GFAP) astrocytopathy, an autoimmune central nervous system disorder with a specific GFAP-IgG, often coexists with other antibodies. The aim of this article was to study overlapping syndromes in autoimmune GFAP astrocytopathy. Antibody was detected by indirect immunofluorescence assay. Patient data were analyzed retrospectively. Thirty patients with positive GFAP-IgG were included, of whom 10 were defined as overlapping syndrome. Four patients with positive aquaporin-4 (AQP4)-IgG, two with N-methyl-d-aspartate receptor-IgG, three with unknown neuronal antibodies, and one with double AQP4 and myelin oligodendrocyte glycoprotein-IgG were identified. GFAP-IgG and other specific antibodies occurred simultaneously at the initial attack in eight patients. The main symptoms included fever, headache, ataxia, psychosis, hypersomnia, dyskinesia, dementia, seizure, myelitis, and optical symptoms. Brain magnetic resonance imaging in four patients revealed characteristic radial enhancing patterns in the white matter. Cortical abnormalities were found in four patients. Other brain abnormalities occurred in the hypothalamus, midbrain, pons, medulla, cerebellum, and meninges. Six patients exhibited lesions in th...Continue Reading

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Citations

May 3, 2020·Expert Review of Neurotherapeutics·Maria A RoccaMassimo Filippi
Feb 7, 2019·Current Opinion in Neurology·Amy KunchokAndrew McKeon
Jun 18, 2020·Therapeutic Advances in Neurological Disorders·Xue-Lin LiHai-Yang Wang
Dec 8, 2020·Frontiers in Neurology·Chen ZhaoDongsheng Fan
Aug 23, 2020·Multiple Sclerosis and Related Disorders·Nahéma IssaFabrice Camou
Feb 27, 2020·Neuroimmunomodulation·Han LinHongbing Guan

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
Statistical Program for Social Sciences

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