Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells

Scientific Reports
Renaud MassartMoshe Szyf

Abstract

We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landscape in the brain between the groups and a remarkable overlap (72%) between differentially methylated probes in T cells and prefrontal cortex. DNA methylation states in the PFC showed robust correlation with pain score of animals in several genes involved in pain. Finally, only 11 differentially methylated probes in T cells were sufficient to distinguish SNI or Sham individual rats. This study supports the plausibility of DNA methylation involvement in chronic pain and demonstrates the potential feasibility of DNA methylation markers in T cells as noninvasive biomarkers of chronic pain susceptibility.

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Citations

Feb 25, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Christoph SchartnerKatharina Domschke
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Datasets Mentioned

BETA
GSE70008

Methods Mentioned

BETA
immunoprecipitation
GTPases
histone acetylation
PCR

Software Mentioned

Ingenuity Pathway analysis
Cytoscape
R package ‘ penalized
Genomatix
WGCNA
NetworkAnalyzer
Ingenuity Pathway Analysis ( IPA )
QMeDIP

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