PMID: 7514196May 1, 1994Paper

Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules

The Journal of Allergy and Clinical Immunology
J A HigginsJ R Lamb

Abstract

The induction of IgE antibodies reactive with the group I allergen of Dermatophagoides species (house dust mite [HDM]), which comprise a major component of the allergic immune response in HDM-atopic individuals, is dependent on the functional activity of specific CD4+ T cells. In this report we demonstrate that for a particular HDM-atopic individual the T-cell response to the group I allergen of Dermatophagoides pteronyssinus (Der p I) is limited to a single region (residues 101-143) of the protein. By mapping the fine antigen specificity with T-cell clones, we observed that the sequence 101-131 of Der p I contains a cluster of at least three overlapping T-cell epitopes. Analysis of the HLA class II restriction specificity of the T-cell clones revealed that the T-cell epitope, residues 110-131, was restricted by HLA-DRB1*0101. In contrast, peptide Der p I, 110-119 was recognized in association with HLA-DPB1*0402. However, the ability of cloned T cells to proliferate to the peptide Der p I, 107-119 presented by HLA-DPB1*0401, HLA-DPB1*0402, and HLA-DPB1*0501 expressing accessory cells illustrates the heterogeneity of the restriction specificity of this region of Der p I. The application of this information in the design of pepti...Continue Reading

Citations

Sep 18, 2007·Immunologic Research·Wayne R Thomas, Belinda J Hales
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Wayne R ThomasWendy-Anne Smith
Jun 30, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Adrian G Letz, Christopher W Calabria
Mar 1, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Malcolm N Blumenthal
Mar 11, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M J Torres-GalvánF Sánchez-García
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Alan P KnutsenHenk Kauffman
Apr 27, 2000·Allergy·M J Torres-GalvánF Sánchez-García
Jan 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Schou
Jan 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C RobinsonG A Stewart
Aug 5, 1998·Allergy·R ValentaD Kraft
Oct 27, 1998·Allergy·W R Thomas, W Smith
Oct 9, 1999·Contact Dermatitis·A M DownsJ E Sansom
Jul 21, 1998·Annals of the New York Academy of Sciences·D BeesonN Willcox
May 15, 1996·The Journal of Clinical Investigation·B ChauhanC J Bellone
Nov 6, 2002·The Journal of Clinical Investigation·Suranjith L SeneviratneGraham S Ogg
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L Lara-MarquezE Yunis
Nov 13, 2013·Clinical Reviews in Allergy & Immunology·Yubao Cui
Jun 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E A L BatemanG S Ogg
Jul 18, 2014·PloS One·William C ReinholdYves Pommier
Jun 26, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J van NeervenJ N Larsen
Mar 27, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W M HowellJ O Warner
Aug 24, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·R M O'BrienW R Thomas
Dec 14, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P A WürtzenR J Van Neerven
Jun 6, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A G Jarnicki, W R Thomas
Oct 28, 2004·Molecular Nutrition & Food Research·Barbara Bohle
Oct 29, 2009·Clinical and Experimental Immunology·S L PrescottF T Christiansen
Feb 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·John SidneyAlessandro Sette
Sep 30, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Carla OseroffAlessandro Sette
Nov 26, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E WambreP Moingeon
Sep 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·John SidneyAlessandro Sette
May 29, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S R PrickettR E O'Hehir
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·W A SmithW R Thomas
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Sara R PrickettRobyn E O'Hehir

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