Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion

Trends in Parasitology
Greta E WeissPaul R Gilson

Abstract

A highly-effective, long-lasting vaccine, targeting multiple stages of the Plasmodium falciparum life cycle, is likely to be important for the elimination of this pathogen. Key antigens of this vaccine would produce host antibodies that block the ligands required for merozoite invasion of erythrocytes, thereby curtailing the expansion of parasitemia and symptomatic disease. Recent live cell imaging of invading Plasmodium falciparum merozoites with various receptor-ligand interactions inhibited has provided new information about the function, sequence, and timing of these events, providing a rationale for a vaccine containing multiple antigens that inhibit the sequential steps of invasion.

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Citations

Nov 1, 2016·PLoS Neglected Tropical Diseases·Jessica B HostetlerJulian C Rayner
Feb 13, 2019·FEMS Microbiology Reviews·Amy L BurnsDanny W Wilson
Jul 22, 2019·Proteins·Shira WarszawskiSarel J Fleishman
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Sep 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Livia Neves Borgheti-CardosoTeresa Sierra
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Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Usheer KanjeeManoj T Duraisingh

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