Overnight urinary growth hormone in normally growing prepubertal children: effect of urine volume. The one-year growth study

Hormone Research
L GelanderK Albertsson-Wikland

Abstract

Growth hormone excretion can easily be measured in the urine using ultrasensitive methods. The large day-to-day variation has, however, restricted its diagnostic usefulness. The present study aimed to evaluate the individual variation of GH in the urine (uGH) during normal prepubertal growth. Eighty-four prepubertal normally growing children were followed monthly for 13 months. During this period, 3,207 overnight urine samples were collected. The urine collection time was unrelated to the uGH concentration (p > 0.05), while there was a significant negative correlation between the uGH concentration and urine volume (the Spearman correlation coefficient of -0.33, p < 0.0001), while the calculated excretion of GH in the urine showed a positive correlation with the urine volume (r = 0.35; p < 0.0001). A reference chart, based on SD scores, was developed in order to avoid this volume dependency and to optimally normalize the skewed distribution of the uGH concentrations. The use of this model reduced the individual day-to-day variation of uGH from a coefficient of variation of 43 to 21%. Differences in mean cross-sectional urinary GH concentration was found between different months exceeding the expected methodological variation. Th...Continue Reading

Citations

Aug 18, 2001·Journal of Endocrinological Investigation·A SartorioG Faglia
Nov 9, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Violeta Popii, Gerhard Baumann
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Tara Sankar RoyTheodore A Slotkin

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