Overnourishment during lactation induces metabolic and haemodynamic heart impairment during adulthood

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Anatalia K G VieiraAnibal Sanchez Moura

Abstract

In this study, the effects of postnatal overfeeding on heart energy homoeostasis and cardiac haemodynamics in adult male Swiss mice were examined. During the suckling period, the mice were divided into four groups of control or overfed pups in combination with baseline or ischaemia/reperfusion treatments (control group baseline, CGBL; overfed group baseline, OGBL; control group ischaemia/reperfusion, CGIR; and overfed group ischaemia/reperfusion, OGIR). End diastolic pressure (EDP), heart contraction speed (Max dP/dt), relaxation speed (Min dP/dt), isovolumetric relaxation time (Tau) and frequency by beats per minute (BPM) were measured. During baseline and ischaemia/reperfusion, key proteins such as AKT1, AKT2, AKT3, pAKT, adenosine monophosphate-activated protein kinase (AMPK), pAMPK, insulin receptor beta (IRβ), protein tyrosine phosphatase 1B (PTP1B), insulin receptor substrate 1 (IRS1), fatty acid binding protein (FABP), CD36, phosphoinositide 3-kinase (PI3K) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) were studied. The expression of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), carnitine palmitoyltransferase 1 (CPT1) and uncoupling protein 3 (UCP3) was studied as ...Continue Reading

References

Jan 1, 1992·Experimental and Clinical Endocrinology·A PlagemannG Dörner
Oct 1, 1992·The American Journal of Cardiology·E K KasperK L Baughman
Nov 1, 1957·The Journal of Endocrinology·G C KENNEDY
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L HeilbronnE Ravussin
Feb 9, 2005·Journal of Molecular and Cellular Cardiology·Yoshiaki TaniyamaIchiro Shiojima
Jun 30, 2006·Regulatory Peptides·Renata Oliveira PereiraAnibal Sanchez Moura
Sep 18, 2007·Circulation Research·Ronghua Yang, Lili A Barouch
Jul 5, 2008·The Journal of Endocrinology·Mariana Renovato MartinsAnibal Sanchez Moura
Aug 19, 2008·The Journal of Nutritional Biochemistry·Alessandra Cordeiro de Souza Rodrigues CunhaAnibal Sanchez Moura
Aug 30, 2008·Experimental Physiology·Melissa E ReicheltJohn P Headrick
Apr 11, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A Seixas Bello MoreiraA Sanchez Moura
Nov 6, 2010·Cardiovascular Research·Qiujun YuXin L Ma
Sep 22, 2011·Current Pharmaceutical Design·Tomohisa NagoshiSeibu Mochizuki
Nov 29, 2011·Journal of Cellular and Molecular Medicine·Suma P KunuthurDerek M Yellon
Mar 13, 2012·Peptides·Glauciane Lacerda-MirandaAnibal S Moura
Dec 11, 2013·The Journal of Endocrinology·Nigel TurnerClinton R Bruce

❮ Previous
Next ❯

Citations

Nov 7, 2016·Cellular and Molecular Life Sciences : CMLS·Tian LiYang Yang
Mar 24, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Marie BesnierAntoine Ouvrard-Pascaud
Oct 29, 2018·Journal of Cellular Biochemistry·Cristiane de Moura FreitasClaudia Jacques Lagranha
Aug 4, 2020·Journal of Nutritional Science·Gracielle Amaral de AraújoChristianne B V Scaramello
Aug 9, 2016·Current Opinion in Lipidology·Elena Loche, Susan E Ozanne
Dec 17, 2020·International Journal of Molecular Sciences·Marie JosseCatherine Vergely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.