Overproduction of transforming growth factor-beta1 (TGF-beta1) is associated with adhesion formation and peritoneal fibrinolytic impairment

Surgery
L HolmdahlN Chegini

Abstract

Reduction in peritoneal fibrinolytic capacity and increased transforming growth factor-beta1 (TGF-beta1) production are associated with adhesion development. This study investigated the expression of TGF-beta1 in peritoneal tissue, and possible correlation with components of the fibrinolytic system locally in peritoneal tissue. Peritoneal samples were taken from 22 patients at relaparotomy. Samples of adhesions were collected from 10 patients. The patients were categorized into different groups depending on the quantity and the quality of adhesions. TGF-beta1 and components of the fibrinolytic system in tissue extracts were assayed using enzyme-linked immunosorbent assays. The concentration of active TGF-beta1 in peritoneal samples from patients with extensive adhesions was double (P <.01) that of healthy subjects, but the total levels of TGF-beta1 were similar (P =.63). In adhesion tissue, both active (P <.003) and total (P <.008) TGF-beta1 concentrations were more than twice as high as unaffected peritoneum. There was a significant correlation between the concentration of plasminogen activator inhibitor type 1 in peritoneal samples with active TGF-beta1 (P <.03, r = 0.693) and adhesion tissue with total TGF-beta1 (P =.001, r ...Continue Reading

References

Oct 1, 1992·American Journal of Respiratory Cell and Molecular Biology·S IdellA R Johnson
Jan 1, 1992·The Journal of Surgical Research·R S WilliamsG Schultz
Jul 1, 1992·The Journal of Clinical Investigation·W A Border, E Ruoslahti
Sep 1, 1991·Progress in Cardiovascular Diseases·J HenkinH C Yang
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Apr 1, 1989·The British Journal of Surgery·J N ThompsonH A Dudley
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Jun 1, 1996·Surgery·L HolmdahlB Risberg
Aug 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·L HolmdahlB Risberg
Feb 4, 1998·Journal of the American College of Surgeons·N F RayS Perry
Nov 21, 1998·The British Journal of Surgery·M L IvarssonL Holmdahl
Dec 29, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·P FalkL Holmdahl
Jul 1, 1997·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·N CheginiL Holmdahl
Jul 1, 1994·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L E HolmdahlB Risberg

❮ Previous
Next ❯

Citations

Mar 3, 2007·Surgical Endoscopy·Walter J A BrokelmanMichael M P J Reijnen
Jun 17, 2010·Surgical Endoscopy·W J A BrokelmanM M P J Reijnen
Aug 19, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rizal LimJames M Becker
Dec 4, 2001·Fertility and Sterility·N CheginiUNKNOWN Pritoneal Healing and Adhesion Multiuniversity Study Group
May 17, 2003·Fertility and Sterility·Marie-Louise IvarssonLena Holmdahl
Nov 28, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Eunice Y HuangTai-Lan Tuan
Jun 29, 2010·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Mare M A LensveltMichel M P J Reijnen
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hakan OzelMustafa Sahin
Feb 2, 2013·World Journal of Emergency Surgery : WJES·Federico CoccoliniFausto Catena
Aug 30, 2008·World Journal of Gastroenterology : WJG·Ronan A Cahill, H Paul Redmond
Dec 16, 2011·World Journal of Gastroenterology : WJG·Hussein M Atta
Nov 22, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Constantinos J Stefanidis, Rukshana Shroff
Mar 4, 2014·American Journal of Surgery·Heng-Fu LinShyr-Chyr Chen
Sep 13, 2014·International Journal of Colorectal Disease·Ankit A ChaturvediHarry van Goor
Jan 6, 2010·World Journal of Surgery·Cheng-Chung FangShyr-Chyr Chen
Jan 23, 2016·International Journal of Surgery·Hussein AttaShereen Gaber
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Lin Zhu, Yu-Qing Zhang
Oct 13, 2012·Current Problems in Surgery·Merril T DaytonAlan R Posner
Jan 16, 2016·Surgery·Chema StrikRichard P G Ten Broek
Sep 8, 2010·American Journal of Surgery·Beat SchnürigerDemetrios Demetriades
Sep 15, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Zhengyu LiDan Zhang
Sep 11, 2010·The Journal of Surgical Research·Tarik SammourAndrew G Hill
Jul 3, 2015·Annals of Surgery·Richard P G ten BroekHarry van Goor
Jun 15, 2007·The Journal of Surgical Research·Tatiana SeguraJeffrey A Hubbell
Jan 16, 2007·Journal of Minimally Invasive Gynecology·Andrew K Davey, Peter J Maher
Jan 8, 2008·Journal of Surgical Oncology·Marcus LangenskiöldMarie-Louise Ivarsson
Feb 19, 2008·The British Journal of Surgery·S WilkoszS Herrick
Jul 24, 2012·American Journal of Reproductive Immunology : AJRI·Sergio PodgaecMauricio Simoes Abrao
Apr 17, 2015·Journal of Hepato-biliary-pancreatic Sciences·Natsuko F InagakiAtsushi Miyajima
May 16, 2015·The Journal of Surgical Research·Kyriakos FotiadisKaterina Kotzampassi
Oct 4, 2011·International Journal of Surgery·Allison H MaciverA M James Shapiro
Jan 21, 2015·Frontiers in Physiology·Zia MoinuddinSarah E Herrick
Dec 22, 2017·The Journal of Pharmacology and Experimental Therapeutics·Lin TianJin Pei
Jun 6, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Geng WangGuobin Wang
Apr 28, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Nicola Cavallini, Magnus Braide

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.