Abstract
Some variants of the glucocorticoid receptor (GR) gene have been found to alter glucocorticoid sensitivity and have been associated with altered metabolic profiles. The objective of the study was to examine whether N363S and ER22/23K variants of the GR gene may be associated with the development of adrenal incidentalomas and whether these variants may contribute to metabolic abnormalities frequently present in these patients. The study included 99 patients with unilateral and 44 patients with bilateral adrenal incidentalomas, 102 population-matched control subjects, and 100 patients with type 2 diabetes mellitus. Metabolic and hormonal parameters and GR gene variants were determined. When compared with control subjects, the carrier frequency for the N363S variant was markedly and significantly higher in patients with bilateral (7.8 vs. 20.5%, P < 0.05) but not in those with unilateral incidentalomas (7.1%) or in patients with type 2 diabetes (13.0%). Type 2 diabetes occurred more frequently in patients with bilateral, compared with those with unilateral incidentalomas (40.9 vs. 22.2%, P < 0.05). In patients with bilateral incidentalomas, a significant association of the N363S variant with impaired glucose homeostasis but not wi...Continue Reading
References
Sep 1, 1968·Acta Medica Scandinavica·H HedelandB Hökfelt
Dec 1, 1994·The Journal of Clinical Endocrinology and Metabolism·G OsellaA Angeli
Aug 1, 1995·Endocrine Reviews·R T KloosB Shapiro
Dec 1, 1996·Journal of Endocrinological Investigation·G P BerniniA Salvetti
May 1, 1997·Human Genetics·J W KoperS W Lamberts
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·R RossiG Lombardi
Sep 6, 2002·European Journal of Endocrinology·Attila PatócsKároly Rácz
Sep 28, 2002·Diabetes·Elisabeth F C van RossumSteven W J Lamberts
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Christian A KochGeorge P Chrousos
Mar 8, 2003·Hypertension·Ruby C Y LinBrian J Morris
Jun 17, 2003·Clinical Endocrinology·Anna Maria Di BlasioSteven W J Lamberts
Jul 17, 2003·Clinical Endocrinology·Ronan RousselGilberto Velho
Jan 30, 2004·Recent Progress in Hormone Research·Elisabeth F C van Rossum, Steven W J Lamberts
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Stefan WüstDirk H Hellhammer
Feb 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Judit MajnikKároly Rácz
Jul 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Henk RusscherJan W Koper
Citations
Feb 22, 2012·Endocrine·Henrik OlsenErik Palmqvist
Jan 29, 2013·International Journal of Hematology·O T EipelG T Kovács
Sep 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Delphine VezzosiJérôme Bertherat
Nov 22, 2012·European Journal of Endocrinology·V MorelliI Chiodini
Apr 20, 2014·European Journal of Endocrinology·Evangeline VassilatouIoanna Tzavara
Sep 17, 2014·Endocrine Journal·Hisaya KawateRyoichi Takayanagi
Dec 24, 2010·Clinical Endocrinology·Dimitra A VassiliadiStylianos Tsagarakis
Mar 11, 2011·Annals of the New York Academy of Sciences·Pierre MormedeMarie-Pierre Moisan
Jun 30, 2010·European Journal of Clinical Investigation·Valentina MorelliIacopo Chiodini
Jan 23, 2016·Clinical Endocrinology·Ágnes MolnárAttila Patócs
Sep 21, 2016·PloS One·Giuseppe ReimondoMassimo Terzolo
Nov 22, 2011·Transplantation Proceedings·K AlbertP Haentjens
Jul 4, 2017·Journal of Medical Biochemistry·Sanja OgnjanovićSvetozar Damjanović
Jul 12, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·George BriassoulisConstantine A Stratakis
Apr 7, 2016·Journal of Pediatric Hematology/oncology·Oliver EipelGábor Kovács
Jun 18, 2014·Endocrine Reviews·Sofie VandevyverClaude Libert
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Henrik OlsenOla Lindgren
Jan 11, 2017·Orphanet Journal of Rare Diseases·Zsuzsanna ZotterHenriette Farkas
Mar 5, 2021·Endocrine Journal·Agena SuzukiMasayoshi Shichiri