Oversight: a retrospective study of biochemical monitoring in patients beginning antihypertensive drug treatment in primary care.

British Journal of Clinical Pharmacology
Jamie J ColemanRobin E Ferner

Abstract

Guidelines recommend biochemical monitoring of patients treated with antihypertensive agents, although there is little primary evidence for these recommendations. Patients treated for hypertension in general practice often have no biochemical tests before, or in the 6 months after, starting drug treatment. Guidelines on the management of hypertension have recommended baseline testing of serum electrolyte and creatinine concentrations before treatment since the 1990s. We wished to examine the extent of laboratory monitoring in patients with newly diagnosed hypertension and newly treated with antihypertensive drugs. We carried out a retrospective analysis of 74,096 patients in the General Practice Research Database (GPRD) aged 18 years and older with newly diagnosed hypertension and prescribed a single antihypertensive agent. We determined the number of patients with a laboratory test for serum electrolyte and creatinine (or urea) concentrations prior to the first antihypertensive drug prescription and in the 6 months after and patient factors associated with subsequent monitoring. Thirty-four thousand nine hundred and forty-seven patients (47%) had at least one biochemical test in the 12 months prior to beginning antihypertensiv...Continue Reading

References

Jan 9, 2001·Archives of Internal Medicine·S A AbookireD W Bates
Aug 22, 2001·JAMA : the Journal of the American Medical Association·D J GrahamM J Burgess
Jun 8, 2002·Pharmacoepidemiology and Drug Safety·James D LewisBrian L Strom
May 14, 2003·Pharmacotherapy·Susan S JickHershel Jick
Nov 25, 2003·BMJ : British Medical Journal·Munir Pirmohamed, Robin E Ferner
Mar 17, 2004·BMJ : British Medical Journal·Bryan WilliamsUNKNOWN BHS guidelines working party, for the British Hypertension Society
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·Janet R HardyMichael B Bracken
Mar 19, 2005·BMJ : British Medical Journal·Paul GlasziouDavid Mant
Apr 29, 2005·Journal of General Internal Medicine·Judith S HurleyFloyd J Frost
Jan 5, 2006·British Journal of Clinical Pharmacology·J A ClaytonI P Hall
Feb 16, 2006·The Annals of Pharmacotherapy·Marsha A RaebelRichard Platt
Mar 18, 2006·British Journal of Clinical Pharmacology·J J ColemanS J W Evans
Jul 11, 2006·Journal of Clinical Pathology·W S A SmellieT M Reynolds
Oct 28, 2006·BMJ : British Medical Journal·Una Martin, Jamie J Coleman
Feb 16, 2007·Pharmacoepidemiology and Drug Safety·Elena TragniAlberico L Catapano

❮ Previous
Next ❯

Citations

Apr 22, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jan C van BlijderveenKatia M Verhamme
Mar 1, 2012·British Journal of Clinical Pharmacology·Stephen J W Evans
Mar 19, 2016·Pharmacoepidemiology and Drug Safety·Matthew L MaciejewskiLesley H Curtis
Mar 23, 2010·Pharmacoepidemiology and Drug Safety·Sarah E McDowellR E Ferner
Mar 14, 2013·Journal of the Royal Society of Medicine·Sarah E McDowellRobin E Ferner
Oct 11, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sarah E McDowell, Robin E Ferner
Jun 15, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Janet E M BootsmaCornelis Kramers
Aug 10, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Edouard L FuJuan-Jesus Carrero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2021 Meta ULC. All rights reserved