Oversulfated chondroitin sulfate proteoglycan in cultured human peritoneal macrophages

Biochemical and Biophysical Research Communications
S O Kolset

Abstract

Human peritoneal macrophages were cultured in vitro and labeled with [35S]-sulfate. Both on day 1 and day 6 in culture the cells were found to synthesize exclusively chondroitin sulfate proteoglycan, the main part (70%) being associated with the medium after a 20 hour pulse. The glycosaminoglycan chains were found to be oversulfated both after 1 and 6 days in culture, due to the presence of disulfated disaccharide units.

References

Sep 7, 1976·Biochemistry·J E Shively, H E Conrad
Mar 17, 1975·Biochemical and Biophysical Research Communications·C B Underhill, J M Keller
Mar 28, 1986·Biochemical and Biophysical Research Communications·D L Carson, C S Baxter
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarM L Jakubowski
Jun 16, 1982·Biochimica Et Biophysica Acta·Y TakasuY Mori

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Citations

Jul 12, 1990·Biochimica Et Biophysica Acta·V L Petricevich, Y M Michelacci
Dec 11, 1990·Biochimica Et Biophysica Acta·S O Kolset, J T Gallagher
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y M Michelacci, V L Petricevich
Jul 26, 2002·Molecular Microbiology·Gabriele PradelUte Frevert
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L StevensK F Austen
Jun 25, 1998·Glycobiology·M A KulsethS O Kolset
Oct 13, 2009·Trends in Biochemical Sciences·Charles N BirtsDavid C Wilton
Mar 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Irani, L B Schwartz
Sep 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J E Christner
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J D LaskinD L Laskin
Feb 1, 1987·Experimental Cell Research·S O Kolset

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