Overt Thyroid Dysfunction and Anti-Thyroid Antibodies Predict Response to Anti-PD-1 Immunotherapy in Cancer Patients.

Thyroid : Official Journal of the American Thyroid Association
Edwin A BasakMarco Medici

Abstract

Background: Thyroid dysfunction is among the most common adverse effects during anti-programmed cell death 1 (PD-1) immunotherapy, and alongside correlations with elevated anti-thyroid antibodies (ATAb), studies have found correlations with survival. However, the exact relations remain to be clarified. We, therefore, aimed at clarifying the relationship between thyroid dysfunction, ATAbs, and survival in anti-PD-1 treated cancer patients. Methods: We included 168 patients with nonsmall-cell lung carcinoma, renal cell carcinoma, and metastatic melanoma treated with nivolumab or pembrolizumab. Thyrotropin and free T4 (fT4) levels were measured before each anti-PD-1 infusion. ATAb levels (anti-thyroid peroxidase [TPO] and anti-thyroglobulin [Tg]) were measured at baseline and after two months of treatment. Although the vast majority of patients had detectable levels of ATABs, only a few patients had positive ATAbs when using conventional cut-offs. To study the consequences of detectable ATABs, the cut-off levels were a priori set at the median concentrations at baseline in the study population. Tumor progression was classified according to RECIST v1.1. Results: Patients who acquired overt thyroid dysfunction during treatment had s...Continue Reading

References

Dec 31, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S ChampiatA Marabelle
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M MichotO Lambotte
Mar 10, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Stephen HodiJedd D Wolchok
Jan 21, 2017·Nature Reviews. Endocrinology·David J ByunMonica Girotra
Sep 25, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shunsuke TeraokaKeisuke Tomii
Oct 14, 2017·Endocrine-related Cancer·Priscilla CukierAna O Hoff
Dec 15, 2017·Journal of Endocrinological Investigation·P ChalanP Caturegli
Jan 2, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Koichi SatoNobuyuki Yamamoto
Mar 31, 2018·Journal of the Endocrine Society·Tomoko KobayashiHiroshi Arima
Dec 13, 2018·Journal of Cancer Research and Clinical Oncology·Alice IndiniMichele Del Vecchio
Jan 18, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Edwin A BasakRon H J Mathijssen
Feb 21, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Matthew LeiDing Wang
Jun 7, 2019·JAMA Oncology·Yukihiro Toi, Shunichi Sugawara
Jun 25, 2019·Journal of the American Academy of Dermatology·Linda ChanPablo Fernandez-Penas

❮ Previous
Next ❯

Citations

Dec 22, 2020·Heliyon·Kanchan KumariUmakanta Subudhi
Feb 13, 2021·Journal of Endocrinological Investigation·C LuongoD Salvatore
Dec 29, 2020·Journal of Endocrinological Investigation·L BrilliM G Castagna
Apr 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Christopher A MuirAlexander M Menzies
Jul 17, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Anupam Kotwal, Mabel Ryder
Sep 19, 2021·International Journal of Cancer. Journal International Du Cancer·Lei XuXiaoping Chen

❮ Previous
Next ❯

Software Mentioned

iRECIST
MULTOMAB
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.