Overtraining and the BCAA hypothesis

Medicine and Science in Sports and Exercise
U A Gastmann, M J Lehmann

Abstract

The purpose of this review was to give an answer to the question whether there are convincing data to support the hypothesis of an amino acid imbalance as one possible mechanism to explain overtraining syndrome. Animal studies point to an enhanced synthesis of the neurotransmitter 5-hydroxytryptamine through an amino acid imbalance at the blood-brain barrier with a preferable tryptophan uptake into the brain, resulting in premature fatigue. Human studies, however, show contradictory results, mainly because of nonstandardized methodology, so that a final conclusion cannot be made at present. BCAA supplementation in addition to standard carbohydrate ingestion during sustained exercise seems to be of no eminent advantage to delay fatigue. The overall results concerning the BCAA hypothesis to explain overtraining are inconclusive and require more controlled experimental research.

References

Apr 12, 1979·European Journal of Applied Physiology and Occupational Physiology·J DécombazJ R Poortmans
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·J M DavisW P Bartoli
May 1, 1992·Acta Physiologica Scandinavica·S P BaileyE N Ahlborn
Apr 1, 1992·International Journal of Sports Medicine·M LehmannN Bachl
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·E BlomstrandE A Newsholme
Jun 1, 1991·International Journal of Sports Medicine·C VervoornJ H Thijssen
Feb 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G D WheelerD C Cumming
Jul 1, 1991·Sports Medicine·R W FryD Keast
Dec 1, 1990·British Journal of Sports Medicine·R Budgett
May 1, 1990·International Journal of Sports Medicine·M Parry-BillingsE A Newsholme
Aug 1, 1990·International Journal of Sports Medicine·A C HackneyB C Bruot
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·A J WagenmakersR H Edwards
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J L BarronR P Millar
Aug 1, 1988·Sports Medicine·H Kuipers, H A Keizer
Dec 1, 1988·International Journal of Sports Medicine·K HäkkinenP V Komi
Jun 1, 1988·Medicine and Science in Sports and Exercise·D L CostillS H Park
Sep 1, 1987·British Journal of Sports Medicine·W P MorganK A Ellickson
Jun 1, 1986·International Journal of Sports Medicine·H AdlercreutzJ Karvonen
Dec 1, 1971·Journal of Applied Physiology·D L CostillK Sparks
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G L DohmR T Williams
Apr 1, 1995·International Journal of Sports Medicine·M LehmannD Häussinger
May 1, 1994·Journal of Applied Physiology·G BruinG J Vander Vusse
Sep 1, 1993·British Journal of Sports Medicine·M LehmannJ Keul
Jul 1, 1993·Medicine and Science in Sports and Exercise·M LehmannJ Keul
Aug 1, 1993·International Journal of Sports Medicine·S P BaileyE N Ahlborn
Apr 1, 1996·International Journal of Sports Medicine·M LehmannD Häussinger
Jan 1, 1996·International Journal of Sports Medicine·S Green, B T Dawson

❮ Previous
Next ❯

Citations

Mar 18, 2006·Arquivos brasileiros de endocrinologia e metabologia·Marcelo Macedo RogeroJulio Tirapegui
May 5, 2020·International Journal of Sports Physiology and Performance·Jinger S GottschallHeather J Porter
Jan 19, 2019·Aging Clinical and Experimental Research·Caroline Pietta-DiasNadja Schröder
Feb 29, 2000·Medicine and Science in Sports and Exercise·L L Smith
Sep 17, 2003·Sports Medicine·André E AubertFrank Beckers
Oct 20, 2000·Medicine and Science in Sports and Exercise·C PetiboisG Déléris
Jan 22, 2005·Current Sports Medicine Reports·Eric J Anish
Jun 14, 2014·Journal of Applied Physiology·Yann Le MeurChristophe Hausswirth
Apr 25, 2017·Pacing and Clinical Electrophysiology : PACE·Kadir Uğur MertEngin Özakin
Oct 24, 2002·Sports Medicine·Cyril PetiboisGérard Déléris
Jun 19, 2004·International Journal of Toxicology·Shoji TsubukuTakeshi Kimura
Jul 20, 1999·Clinics in Sports Medicine·M H Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Medicine and Science in Sports and Exercise
Sarah R JackmanKevin D Tipton
International Journal of Sport Nutrition and Exercise Metabolism
M H Hargreaves, R Snow
© 2022 Meta ULC. All rights reserved