Overview and Critical Appraisal of Arterial Spin Labelling Technique in Brain Perfusion Imaging

Contrast Media & Molecular Imaging
Amirah AlsaediXavier Golay

Abstract

Arterial spin labelling (ASL) allows absolute quantification of CBF via a diffusible intrinsic tracer (magnetically labelled blood water) that disperses from the vascular system into neighbouring tissue. Thus, it can provide absolute CBF quantification, which eliminates the need for the contrast agent, and can be performed repeatedly. This review will focus on the common ASL acquisition techniques (continuous, pulsed, and pseudocontinuous ASL) and how ASL image quality might be affected by intrinsic factors that may bias the CBF measurements. We also provide suggestions to mitigate these risks, model appropriately the acquired signal, increase the image quality, and hence estimate the reliability of the CBF, which consists an important noninvasive biomarker. Emerging methodologies for extraction of new ASL-based biomarkers, such as arterial arrival time (AAT) and arterial blood volume (aBV), will be also briefly discussed.

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Citations

Aug 19, 2018·Journal of Neurology·Avinash ChandraUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 15, 2020·Journal of Magnetic Resonance Imaging : JMRI·Sven BambachMai-Lan Ho
May 7, 2021·Frontiers in Neuroendocrinology·Yaqiong WangGuang Ning

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Methods Mentioned

BETA
biopsies

Software Mentioned

FAIR
PASL
CASL
EPISTAR
QUIPSS
PCASL
PICORE

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