Overview of adult congenital heart transplants

Annals of Cardiothoracic Surgery
Roosevelt Bryant, David Morales

Abstract

Transplantation for adult patients with congenital heart disease (ACHD) is a growing clinical endeavor in the transplant community. Understanding the results and defining potential high-risk patient subsets will allow optimization of patient outcomes. This review summarizes the scope of ACHD transplantation, the mechanisms of late ventricular dysfunction, the ACHD population at risk of developing heart failure, the indications and potential contraindications for transplant, surgical considerations, and post-transplant outcomes. The findings reveal that 3.3% of adult heart transplants occur in ACHD patients. The potential mechanisms for the development of late ventricular dysfunction include a morphologic systemic right ventricle, altered coronary perfusion, and ventricular noncompaction. The indications for transplant in ACHD patients include systemic ventricular failure refractory medical therapy, Fontan patients failing from chronic passive pulmonary circulation, and progressive cyanosis leading to functional decline. Transplantation in ACHD patients can be quite complex and may require extensive reconstruction of the branch pulmonary arteries, systemic veins, or the aorta. Vasoplegia, bleeding, and graft right ventricular dy...Continue Reading

Citations

May 31, 2020·Heart Failure Reviews·James MonacoPrateeti Khazanie
Mar 10, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Maruti HaranalOsami Honjo
Sep 11, 2020·Current Cardiology Reports·Payton Kendsersky, Richard A Krasuski
May 7, 2020·Current Opinion in Anaesthesiology·Pablo MottaLuis M Zabala
Aug 26, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Aisling McMahonMichael Griffin
Dec 12, 2020·Scientific Reports·Tomomi Kogiso, Katsutoshi Tokushige
Jan 22, 2021·Clinical Transplantation·Atsushi KainumaKoji Takeda
Sep 20, 2020·The Annals of Thoracic Surgery·Atsushi KainumaKoji Takeda
Apr 28, 2020·The Journal of Thoracic and Cardiovascular Surgery·Oliver K Jawitz, Vignesh Raman
May 28, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Alessandra Verzelloni SefUlrich Stock
Dec 4, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Katia Bravo-JaimesAri Cedars

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.