PMID: 9429131Jan 16, 1998Paper

Overview of lamotrigine and the new antiepileptic drugs: the challenge

Journal of Child Neurology
J M Pellock

Abstract

Lamotrigine, like all antiepileptic drugs, can be effective when used as monotherapy or adjunctive therapy. In general, adverse effects are reduced when monotherapy is employed. The most frequent adverse effect prompting withdrawal of lamotrigine is rash. This potentially life-threatening adverse effect occurs more frequently in children, is increased when a rapid dose titration schedule is employed, and is greater when lamotrigine, is prescribed in combination with valproate. The availability of lamotrigine and other antiepileptic drugs represents a major advance for the treatment of childhood epilepsy. The challenge in using all of the new antiepileptic drugs, including lamotrigine, is to balance the expected improved efficacy with the potentially serious adverse effects.

References

Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Mar 1, 1996·Drugs·L D Morton, J M Pellock
Feb 1, 1997·Seizure : the Journal of the British Epilepsy Association·F M BesagE L Mullens
Mar 1, 1997·Seminars in Pediatric Neurology·J M Pellock, N Watemberg
Mar 1, 1997·Seminars in Pediatric Neurology·F E Dreifuss

❮ Previous
Next ❯

Citations

Mar 11, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Eun Yeon JooMann Hyung Lee
Aug 11, 2000·Pharmacotherapy·J M Pellock
Jun 5, 2012·European Journal of Clinical Pharmacology·Surulivelrajan MallaysamyDevarakonda Ramakrishna
Dec 6, 2006·Expert Review of Neurotherapeutics·Sheetal MalikLawrence J Hirsch
Oct 26, 1999·Epilepsia·J M Pellock, R Appleton
Feb 24, 2001·The Annals of Pharmacotherapy·V BitonUNKNOWN Topiramate TPS-TR Study Group
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
Feb 24, 2001·Journal of Child Neurology·T A Glauser
Mar 2, 2005·Acta Neurologica Scandinavica·S P-Codrea TigaranM Dam
Mar 19, 2020·Pharmacogenetics and Genomics·Taraswi Mitra-GhoshRuss B Altman
Apr 16, 2002·Epilepsia·John W GibbsDouglas A Coulter
Jun 15, 2020·Journal of Pharmaceutical Sciences·Cinthya Eloisa Chávez-CastilloSilvia Romano-Moreno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.