Overview of Mitochondrial Bioenergetics

Methods in Molecular Biology
Vitor M C Madeira

Abstract

Bioenergetic science started in the eighteenth century with the pioneer works by Joseph Priestley and Antoine de Lavoisier on photosynthesis and respiration, respectively. New developments were implemented by Pasteur in the 1860s with the description of fermentations associated with microorganisms, further documented by Buchner brothers who discovered that fermentations also occurred in cell extracts in the absence of living cells. In the beginning of the twentieth century, Harden and Young demonstrated that orthophosphate and other heat-resistant compounds (cozymase), later identified as NAD, ADP, and metal ions, were mandatory in the fermentation of glucose. The full glycolysis pathway has been detailed in the 1940s with the contributions of Embden, Meyeroff, Parnas, and Warburg, among others.Studies on the citric acid cycle started in 1910 (Thunberg) and were elucidated by Krebs et al. in the 1940s.Mitochondrial bioenergetics gained emphasis in the late 1940s and 1950s with the works of Lehninger, Racker, Chance, Boyer, Ernster, and Slater, among others. The prevalent "chemical coupling hypothesis" of energy conservation in oxidative phosphorylation was challenged and replaced by the "chemiosmotic hypothesis" originally form...Continue Reading

Citations

Aug 17, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wei-Wei CaiFang Wei
Feb 7, 2020·Physiology·Russel J ReiterRamaswamy Sharma
Mar 24, 2020·Thyroid : Official Journal of the American Thyroid Association·Flavia Fonseca BloiseTânia Maria Ortiga-Carvalho
May 6, 2021·Biomedicines·Hilary Y LiuElias Aizenman

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