PMID: 15218803Jun 29, 2004Paper

Overview of primary progressive multiple sclerosis (PPMS): similarities and differences from other forms of MS, diagnostic criteria, pros and cons of progressive diagnosis

Multiple Sclerosis : Clinical and Laboratory Research
A J Thompson

Abstract

Patients with the primary progressive form of multiple sclerosis (PPMS) have a unique clinical course and demonstrate additional demographic and imaging features, which separate them from the relapsing/remitting form of the condition. Whether these features indicate a fundamental difference in the underlying pathogenesis of the condition or simply reflect opposite ends of a clinical spectrum is unclear. What is clear, however, is that this form of MS provides a valuable model of progression, which has the potential to explain this most disabling component of the disease process. The lack of the hallmark relapses and remissions in PPMS poses diagnostic difficulties, some of which have been addressed by recently published diagnostic criteria. Following diagnosis, the need for information, specific to this form of MS, must be recognized and addressed.

References

Jul 1, 1988·Acta Neurologica Scandinavica·J M MinderhoudA J Prange
Aug 1, 1994·Brain : a Journal of Neurology·T ReveszW I McDonald
Jan 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·D KiddA J Thompson
Jun 1, 1997·Brain : a Journal of Neurology·A J ThompsonJ De Sá
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G V McDonnell, S A Hawkins
Jul 23, 1998·Neurology·V L StevensonA J Thompson
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·M KremenchutzkyG C Ebers
May 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·V L StevensonA J Thompson
Nov 18, 2000·The New England Journal of Medicine·C ConfavreuxP Adeleine
Jul 28, 2001·Multiple Sclerosis : Clinical and Laboratory Research·O Neuhaus, H P Hartung
May 7, 2002·Multiple Sclerosis : Clinical and Laboratory Research·G T IngleA J Thompson
May 7, 2002·Multiple Sclerosis : Clinical and Laboratory Research·W BrückH Lassmann
Jun 27, 2002·Journal of the Neurological Sciences·G V McDonnell, S A Hawkins
Feb 1, 2003·Journal of the Neurological Sciences·Jerry S Wolinsky, UNKNOWN PROMiSe Study Group
Aug 7, 2003·Brain : a Journal of Neurology·G T IngleA J Thompson

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Citations

Jun 21, 2007·Journal of Neurology·M DebouverieH Vespignani
Sep 17, 2009·Journal of Neurology·Lisa HolperJürg Kesselring
Nov 26, 2015·Annals of Neurology·Orhun H KantarciDarin T Okuda
May 14, 2008·Journal of the Neurological Sciences·Claudia Cristina Ferreira VasconcelosRegina Maria Papais Alvarenga
Nov 3, 2007·Journal of the Neurological Sciences·Douglas R DenneyBrett A Parmenter
Mar 31, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Christopher M HollandCharles R G Guttmann
Sep 18, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eleonora TavazziMarco Rovaris
Mar 1, 2016·Statistics in Medicine·Monika JelizarowJelle J Goeman
Feb 1, 2007·Multiple Sclerosis : Clinical and Laboratory Research·J H Simon
Nov 11, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Castelo-BrancoJ Hillert
Jan 10, 2014·Multiple Sclerosis : Clinical and Laboratory Research·L J BalkA Petzold
Jul 17, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Devon S ConwayRobert J Fox
Nov 22, 2016·Journal of Neuroscience Research·Lisa C Golden, Rhonda Voskuhl
Dec 15, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Sofia StraudiNino Basaglia
Jan 9, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Rhonda R VoskuhlYuichiro Itoh
Oct 23, 2018·Neurology. Neuroimmunology and Neuroinflammation·Amal P R SamaraweeraNikos Evangelou

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