Overview of proteomics studies in obstructive sleep apnea

Sleep Medicine
Amélia FelicianoDeborah Penque

Abstract

Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.

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Citations

May 29, 2016·Sleep Medicine Clinics·Abdelnaby KhalyfaDavid Gozal
Oct 27, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria R BonsignoreJosep M Montserrat
Feb 15, 2021·Sleep Medicine Reviews·Lucía PinillaDavid de Gonzalo-Calvo
Mar 12, 2021·Sleep·Atul MalhotraDaniel J Gottlieb

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