Overview of rodent models for obesity research

Current Protocols in Neuroscience
Matthias H Tschöp, M L Heiman

Abstract

Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (e.g., high-fat diet-induced obesity), spontaneous mutants (i.e., ob/ob mice), genetically engineered animals (e.g., mice with melanocortin receptor subtype-4 gene disruption (knock-out), or mechanical intervention (e.g., chemical lesion of the ventromedial hypothalamus). This unit reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.

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Citations

Apr 4, 2012·Current Protocols in Neuroscience·Didier BagnolAndrew J Grottick
Oct 29, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K StemmerS Divanovic

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