Overview of role of the immune system in the pathogenesis of inflammatory bowel disease

Advances in Experimental Medicine and Biology
T T MacDonald, G Monteleone

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are caused by the over-activity of the immune system. Current and novel therapies are designed to dampen these over-active responses. Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases. The former has the molecular imprints of a Th1 dominant cell-mediated hypersensitivity response whereas the latter appears to involve antibody-mediated hypersensitivity.

Citations

Nov 28, 2013·World Journal of Gastroenterology : WJG·Orna NitzanWalid Saliba
Jul 21, 2010·Inflammatory Bowel Diseases·Xiaochen ShuKari Hemminki
Jul 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Daniel J MulderChristopher J Justinich
Dec 21, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mel Pilar EspaillatLina M Obeid
Feb 14, 2009·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Robert E Gilbert
Oct 5, 2010·Bioorganic & Medicinal Chemistry Letters·Efrat HarelBoaz Tirosh

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